... in murine models of Alzheimer's disease (AD) to export amyloid beta (Abeta) from the endothelial cells of the blood–brain barrier to the periphery, and that pharmaceutical activation of ABCC1 can reduce amyloid plaque deposition in the brain. Here, we show that ABCC1 is not only capable of exporting Abeta...

... amyloidogenic proteins in C aenorhabditis   elegans ( Burkewitz et al., 2011 ) and yeast ( Han and Emr, 2011 ; Oeser et al., 2016 ). Also, in yeast, hyperosmotic shock can influence the disappearance and appearance of prion amyloids ( Newnam et al., 2011 ; Tyedmers et al., 2008 ). Notably, protein...

...Michael H. Hayes; Daniel L. Weeks ABSTRACT A hallmark of Alzheimer's, Huntington's and similar diseases is the assembly of proteins into amyloids rather than folding into their native state. There is an increasing appreciation that amyloids, under specific conditions, may be non-pathogenic. Here we...

... ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. C. elegans molting larvae amyloid cuticle ABU/PQN innate immunity unfolded protein response Ecdysozoa, the clade of animals defined by the presence...