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Keywords: Amphiregulin
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Journal Articles
Biol Open (2017) 6 (8): 1174–1179.
Published: 27 June 2017
...Vishnu Hosur; Benjamin E. Low; Leonard D. Shultz; Michael V. Wiles ABSTRACT In humans, gain-of-function (GOF) mutations in RHBDF2 cause the skin disease tylosis. We generated a mouse model of human tylosis and show that GOF mutations in RHBDF2 cause tylosis by enhancing the amount of amphiregulin...
Journal Articles
Biol Open (2014) 3 (12): 1151–1157.
Published: 13 November 2014
... identified a previously reported suppressor of cub , called Mcub ( modifier of curly bare ), and find it to be a loss of function allele of the amphiregulin gene ( Areg ). Amphiregulin is an activating ligand of the epidermal growth factor receptor (EGFR) that, like TNF, is released by TACE. Our results...