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Keywords: Amino-oxyacetate
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Journal Articles

Blockage of glutamine-dependent anaplerosis affects mTORC1/2 activity and ultimately leads to cellular senescence-like response

Geng-You Liao, Ming-Ting Lee, Jhen-Jia Fan, Pei-Wen Hsiao, Chun-Sheng Lee, Shou-Yi Su, Jiuan-Jiuan Hwang, Ferng-Chun Ke
Journal: Biology Open
Biol Open (2019) 8 (5): bio038257.
https://doi.org/10.1242/bio.038257
Published: 17 May 2019
... mechanism by employing a pharmacological inhibitor of glutamine-dependent anaplerosis, amino-oxyacetate (AOA). Using the WI38 normal human embryonic fibroblast cell line, we found that exposure to AOA induced mTORC1 inactivation−mTORC2 activation (within day 1), cell cycle arrest (day 2–6) and cellular...
View articletitled, Blockage of glutamine-dependent anaplerosis affects mTORC1/2 activity and ultimately leads to cellular senescence-like response
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Includes: Supplementary data