... formation. During the pathogenesis of Alzheimer's disease (AD), many of the earliest degenerative changes are seen within the EC. Neurodegeneration in the EC and hippocampus during AD has been clearly linked to impairments in memory and cognitive function, and a growing body of evidence indicates...

... in murine models of Alzheimer's disease (AD) to export amyloid beta (Abeta) from the endothelial cells of the blood–brain barrier to the periphery, and that pharmaceutical activation of ABCC1 can reduce amyloid plaque deposition in the brain. Here, we show that ABCC1 is not only capable of exporting Abeta...

... and fission) and cellular energy generation. Thus, Miro might be associated with the key pathologies of several neurodegenerative diseases (NDs) including Alzheimer's disease (AD). In the present manuscript, we have demonstrated the possible genetic interaction between Miro and AD-related genes such as Tau...

... we explored the consequences of increasing contacts between mitochondria and the ER in flies using a synthetic linker. We showed that enhancing MERCs increases locomotion and extends lifespan. We also showed that, in a Drosophila model of Alzheimer's disease linked to toxic amyloid beta (Aβ), linker...

... radiation has beneficial effects in human amyloid-β42 (Aβ42)-expressing Drosophila Alzheimer's disease (AD) models. Ionizing radiation at a dose of 0.05 Gy suppressed AD-like phenotypes, including developmental defects and locomotive dysfunction, but did not alter the decreased survival rates and longevity...

...Liza Bergkvist; Linnea Sandin; Katarina Kågedal; Ann-Christin Brorsson ABSTRACT The aggregation of the amyloid-β (Aβ) peptide into fibrillar deposits has long been considered the key neuropathological hallmark of Alzheimer's disease (AD). Aβ peptides are generated from proteolytic processing...

...Ramesh J. L. Kandimalla; Sudesh Prabhakar; Willayat Yousuf Wani; Alka Kaushal; Nidhi Gupta; Deep Raj Sharma; V. K. Grover; Neerja Bhardwaj; Kajal Jain; Kiran Dip Gill Summary The two hallmarks of Alzheimer's disease (AD) are neurofibrillary tangles and amyloid plaques. Neurofibrillary tangles...

... disease Amyloid β α-secretase β-secretase ADAM10 BACE1 Excessive production of pathogenic amyloid-β (Aβ) peptide from amyloid-β precursor protein (APP) is considered as the biochemical hallmark of Alzheimer's disease ( Haass and Selkoe, 2007 ). Aβ formation requires proteolytic cleavage...