... of studies have described how changes in the expression of individual genes characterize cell types across ontogeny and phylogeny. However, little attention has been paid to the fact that different transcripts can arise from any given gene through alternative splicing (AS). Considered a key mechanism...

...Xukun Lu; Zhen-Ao Zhao; Xiaoqing Wang; Xiaoxin Zhang; Yanhua Zhai; Wenbo Deng; Zhaohong Yi; Lei Li ABSTRACT Alternative splicing (AS) and alternative promoter (AP) usage expand the repertories of mammalian transcriptome profiles and thus diversify gene functions. However, our knowledge about...

... as a result of alternative splicing. All isoforms are transmembrane proteins that differ by just one EGF-like repeat in their extracellular portion. Unlike Crb_A, which is expressed in most embryonic epithelia from early stages onward, Crb_C is expressed later and only in a subset of embryonic epithelia...

...-specific hexokinase 1 isoform and thus is essential for ‘rewiring’ of glycolytic network. Hexokinase Myristoylation Protein acylation Atypical localization Alternative splicing The diversified cellular requirements within a constantly changing environment have made cells to evolve...

... recommend to broaden the second criterion to consider also p53-dependent alternatively spliced or transcribed genes as genuine p53 targets. One of the important findings of our study is the very high overlap between p53-bound and –regulated genes ( Fig. 3C ). Although we only validated p53 binding...