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Keywords: Acid sphingomyelinase
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Journal Articles
Biol Open (2019) 8 (10): bio040311.
Published: 17 October 2019
...Xiahui Xiong; Chia-Fang Lee; Wenjing Li; Jiekai Yu; Linyu Zhu; Yongsoon Kim; Hui Zhang; Hong Sun ABSTRACT In human, loss of acid sphingomyelinase (ASM/SMPD1) causes Niemann–Pick disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (4): 429–435.
Published: 9 March 2016
...-derived proteins and lipids, including ceramide. Sortilin is a transmembrane receptor implicated in the trafficking of acid sphingomyelinase, which is responsible for catalysing the breakdown of sphingomyelin to ceramide. In this study, we examined the role of sortilin in Chlamydia trachomatis L2...
Includes: Supplementary data