...Dimitriya H. Garvanska; Marie Sofie Yoo Larsen; Jakob Nilsson ABSTRACT The spindle assembly checkpoint (SAC) inhibits the anaphase-promoting complex/cyclosome (APC/C) in response to unattached kinetochores by generating a diffusible inhibitor termed the mitotic checkpoint complex (MCC...

...://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Mitosis Spindle assembly checkpoint Metaphase Cenp-E BubR1 APC/C Kinetochore During normal mitosis, faithful chromosome...

...Toshiyuki Hatano; Greenfield Sluder Summary Mother–daughter centriole disengagement, the necessary first step in centriole duplication, involves Plk1 activity in early mitosis and separase activity after APC/C activity mediates securin degradation. Plk1 activity is thought to be essential...