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Keywords: APC/C
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Journal Articles

Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C

Dimitriya H. Garvanska, Marie Sofie Yoo Larsen, Jakob Nilsson
Journal: Biology Open
Biol Open (2016) 5 (10): 1441–1448.
https://doi.org/10.1242/bio.020842
Published: 2 September 2016
...Dimitriya H. Garvanska; Marie Sofie Yoo Larsen; Jakob Nilsson ABSTRACT The spindle assembly checkpoint (SAC) inhibits the anaphase-promoting complex/cyclosome (APC/C) in response to unattached kinetochores by generating a diffusible inhibitor termed the mitotic checkpoint complex (MCC...
View article titled, Synergistic inhibition of the <span class="search-highlight">APC</span>&#x2F;<span class="search-highlight">C</span> by the removal of APC15 in HCT116 cells lacking UBE2C
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Includes: Supplementary data
Journal Articles

Cenp-meta is required for sustained spindle checkpoint

Thomas Rubin, Roger E. Karess, Zohra Rahmani
Journal: Biology Open
Biol Open (2014) 3 (6): 522–528.
https://doi.org/10.1242/bio.20148490
Published: 29 May 2014
... attributed. Mitosis Spindle assembly checkpoint Metaphase Cenp-E BubR1 APC/C Kinetochore During normal mitosis, faithful chromosome segregation is assured by the robustness of kinetochore attachment to the spindle microtubules (K–MT attachments) and the surveillance mechanism called...
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Includes: Multimedia, Supplementary data
Journal Articles

The interrelationship between APC/C and Plk1 activities in centriole disengagement

Toshiyuki Hatano, Greenfield Sluder
Journal: Biology Open
Biol Open (2012) 1 (11): 1153–1160.
https://doi.org/10.1242/bio.20122626
Published: 14 September 2012
...Toshiyuki Hatano; Greenfield Sluder Summary Mother–daughter centriole disengagement, the necessary first step in centriole duplication, involves Plk1 activity in early mitosis and separase activity after APC/C activity mediates securin degradation. Plk1 activity is thought to be essential...
View article titled, The interrelationship between <span class="search-highlight">APC</span>&#x2F;<span class="search-highlight">C</span> and Plk1 activities in centriole disengagement
Open the PDF for The interrelationship between <span class="search-highlight">APC</span>/<span class="search-highlight">C</span> and Plk1 activities in centriole disengagement in another window
Includes: Supplementary data