Issues

Summary: Endoplasmic reticulum (ER) stress plays an important role in hereditary spastic paraplegias (HSPs) pathology, providing new opportunities for HSP treatment.

Summary: Using a Drosophila model of glioblastoma (GB), we describe the temporal organisation of the main cellular events that occur in GB, including cell-to-cell interactions, neurodegeneration and tumour microtubes expansion.

Summary: This study compares the spontaneous behavior and exhaustive exercise of four warm-water fish.

Summary: Tau inhibits axonal transport by blocking kinesin translocation or as kinesin cargo. Tau capable and incapable of microtubule binding inhibited transport equally, indicating inhibition of axonal transport as kinesin cargo.

Summary: This study is the first of its kind that practically investigated the combined exposure of major early life stressors like protein malnourishment and viral and bacterial infections on the nervous system.

Summary: This research describes a functional in vitro model of cardiac hypertrophy, and how the time of stimulation with endothelin-1 affects the cells.

Summary: In four diverse bird radiations, we reveal the presence of complementary colors, putatively for higher contrast. Color patterns may have diversified by redistributing a complementary color pair over the body.

Summary: We show that fruit flies with shortened sleep patterns have decreased aging rates and increased longevity, while flies with disrupted circadian rhythm have decreased longevity. Our data suggests that circadian and sleep systems interact differentially with mechanisms of aging.

Summary: By using naturally-occurring mutations in a human disease, we demonstrate the critical role of endogenous STAT3 in modulating reprogramming efficiency in human somatic cells.

Summary: In this study, we developed a tamoxifen-inducible transgenic mouse model that closely mimics the age-related onset of pancreatic cancer (PC). We showed that activation of Kras (iKC) specifically regulates transcription factors that promote mucin expression and acinar to ductal metaplasia, whereas, loss of Kras^G12D allele in PC cells resulted in the reduction of mucin proteins such as MUC1, MUC4, MUC5AC and MUC16.

Summary: Our research is the first report of developing sensor probes to detect activated-CAPN3 in cultured skeletal muscle cells.

Summary: Our study suggests that overexpression of Miro improves the Alzheimer's disease-related pathologies by decreasing the rough eye phenotype, oxidative stress, apoptosis and neurodegeneration and increasing the lifespan, body weight, phototaxis and climbing activity in the Drosophila model of Alzheimer's disease.