Issues
-
Cover image
Cover Image
Cover: Nuclei of cholinergic neurons of the adult Drosophila brain, pseudo-coloured using depth coding. From a study by Estacio-Gómez and colleagues. Image licensed under a Creative Commons Attribution 4.0 International license.
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
RESEARCH ARTICLES
Dynamic neurotransmitter specific transcription factor expression profiles during Drosophila development
Summary: Transcriptome profiling of cholinergic, GABAergic and glutamatergic neurons in Drosophila identified multiple transcription factors as potential regulators of neurotransmitter fate.
Advanced oxidation protein products change biological behaviors of rat endometrial epithelial cells by activating ERK/P38 signaling pathways
Summary: The research indicated that the accumulation of AOPPs could promote rat endometrial epithelial cells proliferation and migration through ERK and P38 signaling pathways both in vivo and in vitro.
Endurance exercise protects aging Drosophila from high-salt diet (HSD)-induced climbing capacity decline and lifespan decrease by enhancing antioxidant capacity
Summary: Increased dFOXO/SOD pathway activity played a key role in mediating endurance exercise resistance to the salt tolerance-induced impairment of climbing capacity and longevity in aging Drosophila.
V-ATPase subunit B plays essential roles in the molting process of the Chinese mitten crab, Eriocheir sinensis
Summary: V-ATPase subunit B may participate in osmoregulation and help with the new epicuticle formation during the molting process of Chinese mitten crab Eriocheir sinensis.
A novel and cost-effective ex vivo orthotopic model for the study of human breast cancer in mouse mammary gland organ culture
Summary: Here, we describe and validate a novel, cost-effective ex vivo orthotopic model to evaluate chemotherapy agents for breast cancer.
DJ-1 promotes epithelial-to-mesenchymal transition via enhancing FGF9 expression in colorectal cancer
Summary: DJ-1 could activate Wnt signaling to enhance FGF9 expression, resulting in enhanced invasive potential and epithelial-to-mesenchymal transition (EMT) in CRC cells. FGF9 predicts poor survival in patients with CRC.
Reissner fibre-induced urotensin signalling from cerebrospinal fluid-contacting neurons prevents scoliosis of the vertebrate spine
Summary: Reissner fibre (RF) is a glycoprotein filament suspended in cerebrospinal fluid (CSF). We show that RF regulates zebrafish spine morphogenesis by regulating Urotensin signalling from CSF-contacting neurons of the spinal cord.
Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia
Summary: A zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays altered morphology, signs of lysosomal storage disorder, and persistent engulfment of apoptotic neurons in microglia as early disease pathology.
A long lost key opens an ancient lock: Drosophila Myb causes a synthetic multivulval phenotype in nematodes
Summary: Despite nematodes having lost their animal-type Myb proteins 500 million years ago, the Caenorhabditis elegans MuvB complex still functionally interacts with the Drosophila melanogaster Myb protein in vitro and in vivo.
RNA-seq analysis and compound screening highlight multiple signalling pathways regulating secondary cell death after acute CNS injury in vivo
Summary: Multiple cellular signalling pathways are involved in the regulation of secondary cell death after nervous system injury.
Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation
Summary: Different prospero mRNA isoforms have different stabilities, depending on an interaction with the RNA binding protein Syncrip. Isoform choice in different cell types controls the expression level of Prospero protein.
Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing
Summary: We show that mitochondrial dynamics proteins are required for epithelial repair. Drp1 loss-of-function leads to defects in the dynamics of cytosolic and mitochondrial calcium, ROS production and F-actin upon wounding.
FIRST PERSON
CORRECTION
Advertisement
A new Editor-in-Chief and new future for Biology Open

Find out more about the changes at the helm of Biology Open from departing Editor-in-Chief Steve Kelly and Director of The Company of Biologists Laura Machesky. And read our interview with new Editor-in-Chief Daniel Gorelick.
A Year at the Forefront of Plasmodesmal Biology

Andrea Paterlini presents a short overview of recent discoveries, innovations, community resources and hypotheses in the field of plasmodesmata biology.
Future Leader Review: Glial plasticity at nervous system transition zones

In our most recent Future Leader Review, Laura Fontenas from Florida Atlantic University highlights recent work on glial cell migration in and out of the spinal cord.
Future Leader Reviews
Our Future Leader Reviews help early-career researchers:
- Establish themselves in their field
- Find a foothold in a new area after a subject change post-PhD/postdoc
- Build their profile for grant, fellowship and job applications
Sustainable Conferencing Initiative

Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share experience about how new technologies and conference formats work in practice.