Dynamic neurotransmitter specific transcription factor expression profiles during Drosophila development
Summary: Transcriptome profiling of cholinergic, GABAergic and glutamatergic neurons in Drosophila identified multiple transcription factors as potential regulators of neurotransmitter fate.
Advanced oxidation protein products change biological behaviors of rat endometrial epithelial cells by activating ERK/P38 signaling pathways
Summary: The research indicated that the accumulation of AOPPs could promote rat endometrial epithelial cells proliferation and migration through ERK and P38 signaling pathways both in vivo and in vitro.
Endurance exercise protects aging Drosophila from high-salt diet (HSD)-induced climbing capacity decline and lifespan decrease by enhancing antioxidant capacity
Summary: Increased dFOXO/SOD pathway activity played a key role in mediating endurance exercise resistance to the salt tolerance-induced impairment of climbing capacity and longevity in aging Drosophila.
V-ATPase subunit B plays essential roles in the molting process of the Chinese mitten crab, Eriocheir sinensis
Summary: V-ATPase subunit B may participate in osmoregulation and help with the new epicuticle formation during the molting process of Chinese mitten crab Eriocheir sinensis.
A novel and cost-effective ex vivo orthotopic model for the study of human breast cancer in mouse mammary gland organ culture
Summary: Here, we describe and validate a novel, cost-effective ex vivo orthotopic model to evaluate chemotherapy agents for breast cancer.
DJ-1 promotes epithelial-to-mesenchymal transition via enhancing FGF9 expression in colorectal cancer
Summary: DJ-1 could activate Wnt signaling to enhance FGF9 expression, resulting in enhanced invasive potential and epithelial-to-mesenchymal transition (EMT) in CRC cells. FGF9 predicts poor survival in patients with CRC.
Reissner fibre-induced urotensin signalling from cerebrospinal fluid-contacting neurons prevents scoliosis of the vertebrate spine
Summary: Reissner fibre (RF) is a glycoprotein filament suspended in cerebrospinal fluid (CSF). We show that RF regulates zebrafish spine morphogenesis by regulating Urotensin signalling from CSF-contacting neurons of the spinal cord.
Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia
Summary: A zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays altered morphology, signs of lysosomal storage disorder, and persistent engulfment of apoptotic neurons in microglia as early disease pathology.
A long lost key opens an ancient lock: Drosophila Myb causes a synthetic multivulval phenotype in nematodes
Summary: Despite nematodes having lost their animal-type Myb proteins 500 million years ago, the Caenorhabditis elegans MuvB complex still functionally interacts with the Drosophila melanogaster Myb protein in vitro and in vivo.
RNA-seq analysis and compound screening highlight multiple signalling pathways regulating secondary cell death after acute CNS injury in vivo
Summary: Multiple cellular signalling pathways are involved in the regulation of secondary cell death after nervous system injury.
Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation
Summary: Different prospero mRNA isoforms have different stabilities, depending on an interaction with the RNA binding protein Syncrip. Isoform choice in different cell types controls the expression level of Prospero protein.
Summary: We show that mitochondrial dynamics proteins are required for epithelial repair. Drp1 loss-of-function leads to defects in the dynamics of cytosolic and mitochondrial calcium, ROS production and F-actin upon wounding.