Issues

Summary: Transcriptome profiling of cholinergic, GABAergic and glutamatergic neurons in Drosophila identified multiple transcription factors as potential regulators of neurotransmitter fate.

Summary: The research indicated that the accumulation of AOPPs could promote rat endometrial epithelial cells proliferation and migration through ERK and P38 signaling pathways both in vivo and in vitro.

Summary: Increased dFOXO/SOD pathway activity played a key role in mediating endurance exercise resistance to the salt tolerance-induced impairment of climbing capacity and longevity in aging Drosophila.

Summary: V-ATPase subunit B may participate in osmoregulation and help with the new epicuticle formation during the molting process of Chinese mitten crab Eriocheir sinensis.

Summary: Here, we describe and validate a novel, cost-effective ex vivo orthotopic model to evaluate chemotherapy agents for breast cancer.

Summary: DJ-1 could activate Wnt signaling to enhance FGF9 expression, resulting in enhanced invasive potential and epithelial-to-mesenchymal transition (EMT) in CRC cells. FGF9 predicts poor survival in patients with CRC.

Summary: Reissner fibre (RF) is a glycoprotein filament suspended in cerebrospinal fluid (CSF). We show that RF regulates zebrafish spine morphogenesis by regulating Urotensin signalling from CSF-contacting neurons of the spinal cord.

Summary: A zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays altered morphology, signs of lysosomal storage disorder, and persistent engulfment of apoptotic neurons in microglia as early disease pathology.

Summary: Despite nematodes having lost their animal-type Myb proteins 500 million years ago, the Caenorhabditis elegans MuvB complex still functionally interacts with the Drosophila melanogaster Myb protein in vitro and in vivo.

Summary: Multiple cellular signalling pathways are involved in the regulation of secondary cell death after nervous system injury.

Summary: Different prospero mRNA isoforms have different stabilities, depending on an interaction with the RNA binding protein Syncrip. Isoform choice in different cell types controls the expression level of Prospero protein.

Summary: We show that mitochondrial dynamics proteins are required for epithelial repair. Drp1 loss-of-function leads to defects in the dynamics of cytosolic and mitochondrial calcium, ROS production and F-actin upon wounding.