Issues

Summary: The leading cause of human male infertility is a failure to resolve spermatids from a germline syncytium during spermatid individualization. Here we characterize a mutation that disrupts this process.

Summary: Green turtles showed immediate cardiac response to exercise during submergence, presumably because they store oxygen primarily in the lungs and need blood circulation to meet the metabolic demand.

Summary: HIV-1 RNA translation may be enhanced through TAR RNA processing by TRBP in collaboration with Dicer, repressing host–cell apoptosis.

Summary: Epigenomics play a role in cell identity and differentiation. We present the DNA methylation landscape of leukemic cells during in vitro differentiation, adding another omics layer to better understand differentiation mechanisms.

Summary: We combine physiological, environmental and evolutionary aspects of fish growth in a state-dependent model where the optimal regulation of growth and survival is achieved through hormonal regulation of behaviour.

Summary: Loss of the apico-basal polarity regulator Crb2b-lf does not affect retinal development but leads to ocular anterior segment defects in old zebrafish.

Summary: The Greb1 transcriptional cofactor is expressed in the vertebrate tailbud and required for axial extension and segmentation of developing vertebrate embryos.

Summary: In response to the change in the epithelial characteristics from esophagus to trachea/bronchus that happens when SOX2 is inactivated, surrounding mesenchymal tissues also change their characteristics accordingly at all axial levels.

Summary: FAM172A inhibits EMT in pancreatic cancer via specifically regulating ERK-MAPK signaling.

Summary: An important steroidal saponin extracted from Rhizoma Paris, Polyphyllin II suppressed cell viability and induced cell apoptosis in liver cancer cells. Low doses of Polyphyllin II also inhibited liver cancer cell migration and invasion.

Summary: Our results provide a better understanding of the culture conditions upon which we could act to trigger tendon cell differentiation from undifferentiated stem cells.