Issues
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Cover image
Cover Image
Cover: This image is a composite of two different life stages of the hydrozoan jellyfish Clytia hemisphaerica; medusa (top), which releases gametes daily in a light-dependent manner, and vegetatively growing colonial polyp (bottom). An improved whole-life cycle culture protocol has been developed to use it as a developmental genetics model, and is described by Lechable and colleagues in this issue. Photos are taken by Alexandre Jan and Marion Lechable. Image licensed under a Creative Commons Attribution 4.0 International license.
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REVIEW
Uncharted routes: exploring the relevance of auxin movement via plasmodesmata
Summary: The review discusses the occurrence and biological relevance of auxin transport via plasmodesmata in plants. Physical modes of transport of this hormone, feedbacks on its movement and evolutionary aspects are included.
RESEARCH ARTICLES
RhoGAP RGA-8 supports morphogenesis in C. elegans by polarizing epithelia
Summary: RGA-8, a protein with membrane binding and actin regulatory motifs, promotes embryonic morphogenesis by localizing active CDC-42 in developing epithelia, and controlling actin and actin motors during cell movements.
Antibiotics in hives and their effects on honey bee physiology and behavioral development
Summary: Antibiotic treatments in bee colonies cause an increase or decrease in rate of behavioral development and lipid stores of workers, affecting fat body–interaction, likely through effects on microbiota.
The role of macrophage migration inhibitory factor in promoting benign prostatic hyperplasia epithelial cell growth by modulating COX-2 and P53 signaling
Summary: This study found high levels of MIF expression in BPH epithelium. MIF promoted BPH epithelial cell growth and participated in the progression of BPH by regulating COX-2 and P53 signaling
Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy
Summary: GRP78 is highly expressed in the lung cancer tissue, and targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by endoplasmic reticulum stress and autophagy.
Influence of maternal diet on offspring survivorship, growth, and reproduction in a sheetweb spider
Summary: A single meal immediately before oviposition is sufficient to influence offspring survival, growth, and daughters' reproduction in the sheetweb spider Hylyphantes graminicola.
Royal jelly attenuates metabolic defects in a Drosophila mutant with elevated TORC1 activity
Summary: Royal jelly (RJ) modulates the reactive oxygen species (ROS) levels and some metabolic defects that associated with hyper TORC1 activity in a Drosophila model.
Squids use multiple escape jet patterns throughout ontogeny
Summary: In this study, we examine the hydrodynamics and kinematics of escape jets in squids throughout ontogeny using 2D/3D velocimetry and high-speed videography.
Amyloid-beta peptide and phosphorylated tau in the frontopolar cerebral cortex and in the cerebellum of toothed whales: aging versus hypoxia
Summary: Immunohistochemical analysis showed positive immunolabeling for amyloid-beta peptide and phosphorylated tau in the cerebral and cerebellar cortex of toothed whales. These findings could be linked to hypoxic phenomena.
METHODS & TECHNIQUES
Fiji plugin for annotating movies with custom arrows
Summary: We present a user-friendly Fiji plugin to annotate movies with custom arrows, thereby providing biologists with no coding experience an easy tool to highlight dynamic processes in their movies.
Assessing methods to quantitatively validate TGFβ-dependent autophagy
Summary: Using various tools including western blotting and immunofluorescence microscopy, it was observed that autophagic flux probes are the most robust tools to quantitatively assess cellular autophagy.
Efficient and crucial quality control of HAP1 cell ploidy status
Summary: Sharing an effective procedure to quality control the near-haploid HAP1 cells for standardized comparison to CRISPR/Cas9 modified versions and demonstrating the need for controlling the spontaneous diploidization of HAP1 cultures.
Progressive tracking: a novel procedure to facilitate manual digitization of videos
Summary: Progressive tracking is a novel procedure for manual point digitization in markerless videos. It allows for tracking points efficiently without the need to click all individual frames.
Inducible modulation of miR-204 levels in a zebrafish melanoma model
Summary: Sarti et al. describe miniCoopR-I inducible vectors, a refined tool to study the impact exerted by pigmentation on melanogenesis (during embryonic development) versus melanomagenesis (in adult zebrafish).
An improved whole life cycle culture protocol for the hydrozoan genetic model Clytia hemisphaerica
Summary: We developed a reliable whole life cycle culture method for the hydrozoan jellyfish Clytia hemisphaerica, a model animal for genetics and developmental biology.
FIRST PERSON
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Daniel Gorelick on Open Access and Read & Publish in Biology Open
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Are reactive oxygen species harmful for aging fruit flies?
Reactive oxygen species (ROS) are associated with aging and neurodegeneration. In their Research Article, Andrew Wodrich and colleagues study this association by manipulating mitochondrial ROS in Cdk5α-KO and wild type fruit flies. The researchers found that changes in three mitochondrial ROS in the brain are related to altered survival in varied and unexpected ways.
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