Issues

Summary: Krüppel-like factor 6, which is triggered by pulmonary injury and promoted by bone morphogenetic protein 9, mediates pulmonary angiogenesis in rat experimental hepatopulmonary syndrome and then aggravates lung dysfunction.

Summary: GAS5, a tumor suppressor, was confirmed to suppress tumorigenesis and development of gastric cancer by sponging miR-106a-5p through the Akt/mTOR pathway, which provides a novel regulatory axis of GC progression.

Summary: Handling in severe cold causes hyperthermia in well-insulated Svalbard ptarmigan. Hence, pronounced cooling in cold-handled poorly insulated birds likely reflects high heat-loss rate rather than a different physiological response.

Summary: Optic fissure fusion, a key retinal morphogenic event highly sensitive to developmental signaling, is directly regulated by ubiquitin-mediated proteasomal degradation uncovering a novel regulatory pathway potentially correlated to incidence of coloboma.

Summary: The Drosophila Cortactin-binding protein Nausicaa regulates actin branching and lamellipodial dynamics through its anchoring of Cortactin in the lamellipodia.

Summary: We quantitatively evaluate a simple model for human walking based on two-spring and find that this model describes many features of human walking.

Summary: Metabolic rate variation is observed between the two sexes and among populations in the Chinese scorpion, with the latter being correlated negatively with local mean temperature and positively with annual days of rainfall.

Summary: Straying mediates ecological interactions and gene flow between salmon populations. Understanding physiological controls and underlying causes of straying by hatchery-produced salmon may help managers minimize deleterious interactions.

Summary: The effectors of the spindle assembly checkpoint are confined with the nuclear compartment of budding yeast, and cannot exchange between nuclei in a binucleate zygote.

Summary: Programmed cell death is generally assumed to be irreversible. Interestingly, we discovered reversible apoptosis. Here, we further demonstrate reversible ferroptosis, thereby adding a new example of reversible programmed cell death.

Summary: Excessive arm swing reduces the vertical angular momentum and ground reaction moment, but not necessarily the energetic cost of transport.

Summary: The juvenile crown-of-thorns starfish has much smaller eyes than adults do, which results in worse spatial resolution. Still, they use the eyes for negative phototaxis seeking shelter.

Summary: In studying protein-restricted diet-mediated interplay between major traits during pre-adult to adult stages in Drosophila melanogaster, we found various existing positive and negative correlations being challenged and supported upon differing diets.

Summary: When equipped with an artificial load, zebra finch diverge from their typical flap-bounding pattern of flight, potentially reducing their muscular efficiency, and adopt more aerodynamically efficient kinematics.

Summary: Conditional deletion of Sufu causes dramatic expansion of neural stem/precursor cells in the neonatal ventricular-subventricular (SVZ) zone. This defect occurs through a Gli3-dependent mechanism resulting in the downregulation of Shh signaling.

Summary: This study highlights Fgf3 in a novel context where it is part of a signalling pathway of critical importance for development of hypothalamic monoaminergic cells in zebrafish.

Summary: Knockout of the Syap1 gene in mice causes a distinct motor behaviour phenotype characterised by reduced initial locomotor activity and impaired rotarod performance.

Summary: A cost-effective device and two methods to measure the circadian rhythm in diurnal and nocturnal fish, providing a reliable entry point for toxicity assessment on circadian rhythm dysregulation in fish.

Summary: We present a system for exposing mice to hypergravity and measuring the effects on their locomotion and activity. We include details of the design and implementation, and example experimental data.