Issues

Summary: Mannitol, a sugar polyol, decreases body size and survival and prolongs development in larval Drosophila melanogaster. The timing of introduction during development affects the magnitude of mannitol's impact on larvae.

Summary: Cytokeratin (CK) and β-catenin are expressed in juvenile testicles and cultivated Xenopus tropicalis immature Sertoli cells (SC). Acrylamide and CHIR99021 disrupted the CK network, immature SC connections and testes development.

Summary: A new Drosophila diabetes model, where ER stress accumulation and apoptosis is induced in IPCs, showed diabetes-like phenotypes including reduced dilp mRNA, increased glucose concentration in hemolymph and growth inhibition.

Summary: Due to the larger fascicle elongation induced by a pre-activation, the effect of the stretch-shortening cycle is enhanced.

Summary: Cichlid fish rely on the sensory channel indicating higher risk when facing incongruent visual and acoustic information during opponent assessment.

Summary: Tadpoles of the common frog (Rana temporaria) exhibit phenotypic plasticity of the intestinal morphology but not of the oral apparatus when raised on diets of different chemical compositions.

Summary: Using the coral model Aiptasia, we show increased thermotolerance at high salinities, concomitant with a reduced reactive oxygen species (ROS) release by algal endosymbionts. This suggests a mechanistic link between osmoadaptation and thermotolerance, mediated by ROS-scavenging osmolytes.

Summary: Using ultrasound measurements of muscle structure and dynamometer measurements of ankle function, we found that longer muscle fascicles positively correlated with increased ankle kinetics.

Summary: Differentially expressed lncRNA and mRNA profiles in circulating exosomes of patients with rheumatic heart disease compared to healthy control.

Summary: Controlled reoxygenation may provide an effective therapeutic strategy for hypoxia-induced tissue injury via regulation of the JAK2/STAT3 signaling pathway. It will help make better informed clinical treatment decisions for cyanotic infants.

Summary: Tnnt2 expression in the outflow tract is essential for cardiac function, and zebrafish is a powerful in vivo model for investigating cardiomyopathy genetics.

Summary: Our study shows that when the thermal environment is not too stressful, plovers choose nest materials to improve egg camouflage, rather than to buffer the risk of egg overheating.

Summary: This study validates the use of different body measurements to estimate body mass. We show a yearly and north-south pattern between them, strongly correlated with net primary production.

Summary: Robust human iPSC reprogramming through the synergy of NANOG, LIN28, and inhibition of DOT1L in modulation of LIN41 expression and the canonical WNT pathway.

Summary: The autophagy-related Djatg8 homologues Djatg8-2 and Djatg8-3 are required for planarian remodeling; we provide an emergent in vivo model organism to study autophagy and the molecular mechanism for planarian remodeling.

Summary: We described a novel straightforward technique termed Ribo-BiFC to visualise assembled ribosomes in Drosophila cells. This technique revealed ribosomes in axons of both developing and mature neurons.

Summary: Automatic video tracking system to measure froglet swimming and characterize the degree of spinal cord damage after spinal cord injury. It can potentially be used to compare the recovery of spinal cord function after different treatments.