Cover: Knockdown of the putative Drosophila gene CG4038 by RNAi in female germ line cells leads to oogenesis arrest during the first mitotic divisions of the cystoblast. The image shows a CG4038 knockdown ovary stained for the germ line marker Vasa (green), the differentiation factor Bag-of-marbles (Bam; red), the cytoskeleton and fusome component α-Spectrin (blue) and DNA (white). CG4038 was identified as a gene downregulated in bam mutant ovaries in an RNA-seq transcriptome analysis performed by Tiwari et al. Image licensed under a Creative Commons Attribution 4.0 International license.
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Nanog regulates Pou3f1 expression at the exit from pluripotency during gastrulation
Summary: Nanog is a key factor for pluripotency, but we show that it has further roles during gastrulation by regulating lineage determinants such as Pou3f1.
Optimization of high endoglucanase yields production from polypore fungus, Microporus xanthopus strain KA038 under solid-state fermentation using green tea waste
Summary: Our findings show that one polypore fungal species Microporus xanthopus strain, KA038, can produce high endoglucanase yields through optimizing production conditions.
Effects of inhibiting mTOR with rapamycin on behavior, development, neuromuscular physiology and cardiac function in larval Drosophila
Summary: Inhibiting mTOR by rapamycin delays pupation, reduced body wall contractions and mouth-hook movements while synaptic transmission appeared normal in larval Drosophila.
Does paternal immunocompetence affect offspring vulnerability to maternal androgens? A study in domestic chickens
Summary: Our study shows that there were no effects of paternal natural antibody line, increased embryonic testosterone exposure or the interaction of both on immunocompetence of chicks.
A unique transgenic mouse model exhibiting a myeloproliferative disease-like phenotype
Summary: We generated a mouse model similar to human myeloproliferative disease-like phenotype. Mutations in Atg4b and overexpression of TMEM207 may lead to myeloproliferative disease in the present model.
Molecular profiling of stem cell-like female germ line cells in Drosophila delineates networks important for stemness and differentiation
Summary: Fruit fly germline stem cell differentiation is accompanied by major changes of the transcriptome that may be regulated at the post-transcriptional level.
The phosphate-solubilizing ability of Penicillium guanacastense and its effects on the growth of Pinus massoniana in phosphate-limiting conditions
Summary: Identification of a phosphate-solubilizing fungus and its first report in the application as a biological fertilizer.
Muc5b-deficient mice develop early histological lung abnormalities
Summary: The gelling mucin MUC5B is essential for the mucociliary clearance at adulthood. Here we show that Muc5b-deficient mice exhibit an early lung inflammation that may lead to respiratory distress.
Star-PAP regulates tumor protein D52 through modulating miR-449a/34a in breast cancer
Summary: Star-PAP is an important regulator of miR-449a/34a and was first identified indirectly regulating TPD52 via modulating miR-449a/34a. Furthermore, Star-PAP-miR-449a/34a-TPD52 axis is involved in proliferation and apoptosis of breast cancer cells.
Heterogeneous response of endothelial cells to insulin-like growth factor 1 treatment is explained by spatially clustered sub-populations
Summary: Here we demonstrate that inconclusive molecular readouts of drug exposure may be due to a highly heterogeneous cellular response associated with distinct cell lineages within a primary cell population.
MiR145-5p inhibits proliferation of PMVECs via PAI-1 in experimental hepatopulmonary syndrome rat pulmonary microvascular hyperplasia
Summary: Our findings provide proof of principle that microRNAs may be useful for the future development of novel therapeutic strategies in HPS.
The conserved metalloprotease invadolysin is present in invertebrate haemolymph and vertebrate blood
Summary: In this study, we show that the conserved metalloprotease invadolysin is present in invertebrate hemolymph and vertebrate blood, suggesting the protein may function in organismal physiology.
Octopus insularis as a new marine model for evolutionary developmental biology
Summary: Cephalopods are trending as new model organisms in development and EvoDevo. Octopus insularis embryos can be easily maintained in laboratory conditions and are amenable for live imaging.
METHODS & TECHNIQUES
A methodological evaluation of the determination of critical oxygen threshold in an estuarine teleost
Summary: The two leading methods of measuring the critical oxygen threshold in fishes are similar in their estimations, regardless of changes to water chemistry.
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