Cover: Insect herbivores depend directly on the density of their host plants and the nature of this relationship varies across time and space. Nerlekar (2018) examines this relationship across time using a tropical perennial herb, Jatropha nana, as a system. Seen in the photograph are the instars of the jewel bug Chrysocoris purpureus feeding on the fruits of Jatropha nana. Image provided by Ashish Nerlekar and licensed under a Creative Commons Attribution 4.0 International license.
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Divergent Hemogen genes of teleosts and mammals share conserved roles in erythropoiesis: analysis using transgenic and mutant zebrafish
Summary: Transgenic and mutant zebrafish lines were created to characterize the expression and functions of Hemogen, a transcription factor involved in the formation of red blood cells and other processes.
Anomalies in the valve morphogenesis of the centric diatom alga Aulacoseira islandica caused by microtubule inhibitors
Summary: It is shown that colchicine blocks mitosis and induces the formation of specific structures, lateral valves, in the diatom Aulacoseira islandica. Paclitaxel, on the other hand, doesn't have any effect on cell division.
Role of murine macrophage in temporal regulation of cortisol- and serotonin-induced adipogenesis in pre-adipocytes when grown together
Summary: Stress-induced obesity is poorly understood in vivo at the molecular level. The current report established a novel molecular basis of adipogenesis in vitro.
Mammalian embryo comparison identifies novel pluripotency genes associated with the naïve or primed state
Summary: Interspecies comparison of mouse, bovine and pig embryos revealed conserved genes which distinguish between naïve and primed pluripotency states, including in human. Some of these genes interfere with the pluripotency network and lead to differentiation.
Coupling integrin dynamics to cellular adhesion behaviors
Summary: Our findings indicate labeling induced changes in dynamic integrin behaviors alter molecular conformation and cellular adhesion-dependent function to demonstrate a coupling between molecular inputs and distinct cellular outputs.
Centrioles without microtubules: a new morphological type of centriole
Summary: Centrioles without microtubules in larvae cells of parasitoid wasps duplicate and form primary cilia without microtubules, in nymph and imago cells centrioles acquire a ‘normal’ structure with nine microtubules triplets.
Seasonally dependent relationship between insect herbivores and host plant density in Jatropha nana, a tropical perennial herb
Summary: This study tests the relationship between insect-herbivore loads and host plant density across multiple time intervals and provides both evidence for and against the predictions of the landmark resource concentration hypothesis.
Identification of additional regulatory RNPs that impact rRNA and U6 snRNA methylation
Summary: The major contributor to ribosome heterogeneity is variation in rRNA modification by methylation and pseudouridylation. Our work provides additional evidence for the regulation of snoRNP activity by regRNPs, which alters levels of methylation.
Involvement of PKCε in FSH-induced connexin43 phosphorylation and oocyte maturation in mouse
Summary: This research clarifies the important role of PKCε in mediating MAPK action on CX43 phosphorylation during FSH-induced oocyte maturation in vitro, and further explores the regulation mechanism of oocyte maturation.
Human trophoblasts are primarily distinguished from somatic cells by differences in the pattern rather than the degree of global CpG methylation
Summary: The placenta may not be as uniquely hypomethylated as previously reported, rather differences in the pattern of CpG methylation are what make it epigenetically distinct.
Biochemical and histological evidence of deteriorated bioprosthetic valve leaflets: the accumulation of fibrinogen and plasminogen
Summary: Fibrinogen was specifically deposited on whole deteriorated tissue valve leaflets, and plasminogen-positive macrophages strongly invaded the areas around calcified bioprosthetic and native tissues.
The STK35 locus contributes to normal gametogenesis and encodes a lncRNA responsive to oxidative stress
Summary: Transcripts from the STK35 locus impact on male and female fertility and on eye development. A lncRNA (Stk35os1) transcript from this locus is upregulated by oxidative stress.
Progressive adaptation of whole-limb kinematics after peripheral nerve injury
Summary: Longitudinal study of four cats documented recovery of locomotor kinematics in one hindlimb following nerve injury and muscle paralysis focused at the ankle joint. Whole-limb length was not conserved immediately, but recovered pre-injury levels gradually through kinematic adjustments distributed across joints.
EB1 contributes to microtubule bundling and organization, along with root growth, in Arabidopsis thaliana
Summary: EB1 proteins affect cortical-microtubule bundling and organization in Arabidopsis thaliana, without significant modulation of microtubule dynamics. They also participate in root growth, further linking microtubules to plant development.
Ectopic otoconial formation in the lagena of the pigeon inner ear
Summary: We identified a new assembly of otoconia in the pigeon lagena. The structure is not innervated or associated with hair cells. Our finding provides new insights into ectopic otoconial formation.
METHODS & TECHNIQUES
Efficient genome editing using CRISPR/Cas9 ribonucleoprotein approach in cultured Medaka fish cells
Summary: In this paper, we report an efficient genome editing method for cultured medaka fish cells using pre-formed CRISPR/Cas9 RNP. This method will be very useful for gene function studies using cultured fish cells.
Correction: Characterization of a cdc14 null allele in Drosophila melanogaster (doi:10.1242/bio.035394)
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