Issues

Summary: Plag1 and Plagl2 are proto-oncogenes that have been studied extensively in cancer. Here we provide the first report of a role for these genes in the developing central nervous system.

Summary: This research reports that drought-induced photosynthesis declines due to stomatal and non-stomatal limitation, which was PSII photoinhibition-dependent on D1 protein and over-reduces the electron transport chain.

Summary: Our medaka model allows for non-invasive and repetitive assessment and is useful in the analysis of fatty liver in which changes in detailed metabolites are identified.

Summary: We used in vitro-rearing methodology to investigate how differences in rearing conditions, including nutrition, affect the morphology, metabolic physiology and gene expression of honey bee queens and workers.

Summary: We report that a chromatin-binding protein PWP1 binds to 5S ribosomal DNA, regulates its epigenetic status and controls nutrient-dependent RNA polymerase III-mediated transcription of 5S ribosomal RNA.

Summary: Single cell RNAseq was used to identify new markers for specific hair cell in the mammalian utricle. With these new markers, the developmental timing of specific types of hair cells was examined.

Summary: A novel mitochondrial DNA mutator murine embryonic fibroblast cell line was created and the effects of the anti-aging compounds rapamycin and AICAR on energy metabolism in these cells was determined.

Summary: Long non-coding RNA PICSAR decreases adhesion and promotes migration of cutaneous squamous cell carcinoma cells by regulating the expression of collagen and fibronectin binding α2β1 and α5β1 integrins.

Summary: The tail region of 15d-PGJ2 plays a important role in modulating the activity of eIF4A protein across species. This implies that the tail region of this prostaglandins can be adapted to design new drugs.

Summary: Phylogenetic and synteny analyses indicate that the vertebrate zona pellucida (ZP) genes encoding egg coat proteins can be classified into eight subfamilies, and the evolutionary origins of these genes are discussed.

Summary: Focal adhesion kinase acts downstream of Wnt5b to mediate basal constriction of neuroepithelial cells during the formation of the midbrain–hindbrain boundary.

Summary: CYP51 displays cytoplasm-to-nucleus translocation in germ cells in mice. CYP51 participates in germ cell meiotic progression and folliculogenesis via regulating the expression of cohesin REC8 and STAG3.

Summary: Dogs and cats offered foods with different macronutrient composition, but equivalent palatability, have different circulating metabolite concentrations that reflect differences in species and food choices.

Summary: Drosophila Ror is a Wnt co-receptor expressed in the nervous system. A Ror null mutant allele is viable and shows genetic interaction with mutations in off-track and off-track2.

Summary: The interaction between integrin β1 and the extracellular matrix differs at the centre of the colony and at the periphery, and is crucial for the survival of embryonic stem cells.

Summary: Sulfate groups borne by adhesive macromolecules play a role in attachment to underwater surfaces in marine invertebrates using non-permanent adhesion, but not in those using permanent or instantaneous adhesion.

Summary: We characterised subtype-specific growth of the different photoreceptor compartments, organelle distribution and the influence of light on the growth of the apical membrane.

Summary: Proteins that are compatible with shotgun proteomics can be isolated from small amounts of adipose tissue at the same time as RNA, facilitating proteogenomics studies in non-model animals.

Summary: Structural characterization of two novel DARPins (designed ankyrin repeat proteins) recognizing the monomeric teal fluorescent protein 1 (mTFP1) and their functionalization for protein manipulation strategies in cultured cells and potentially in living organisms.