Summary: We provide a pig model for both genetic and pathological studies of human MPS IIIB, which would contribute to timely diagnoses and better treatments of this rare disease.
Summary: Hypoxia ischemia (HI) induces an increase of gliosis and redistribution of prosaposin and cathepsin D into the cytosol of rat hippocampus. This could be triggered by LAMP-1 cleavage in HI.
Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3
Summary: Survivin binds to LC3 through a canonical LIR, yet this interaction is not required for survivin overexpression to reduce autophagic flux, suggesting that survivin regulates autophagy via an alternative mechanism.
Plasma membrane damage caused by listeriolysin O is not repaired through endocytosis of the membrane pore
Summary: Using reporter systems and real-time imaging, we show that endocytic pathways are not directly involved in removal of LLO pores from the plasma membrane.
Summary: Fish exhibit flow-induced changes in their fast-start escape performance, likely due to an in situ training effect and/or selection for faster performance phenotypes in areas with high flow speed.
Hybridization between char species (Salvelinus alpinus and Salvelinus fontinalis): a fast track for novel allometric trajectories
Summary: This research provides a comprehensive overview of the phenotypic modifications in growth trajectories of body size and internal organs following interspecific hybridization in chars.
Summary: Cells that gain or lose chromosomes during cell division are shown to be sensitive to ATP levels and protein folding stress.
Red cell distribution width as a predictor of multiple organ dysfunction syndrome in patients undergoing heart valve surgery
Summary: This is a single-centre study with a limited number of patients. The results of our research may be helpful in the perioperative strategy in patients undergoing heart valve surgery.
Summary: We provide evidence of acoustic trauma in cephalopod hatchling sensory cells after sound exposure, whose damage increases faster than in adults, suggesting a critical period of sensitivity to anthropogenic noise in early stages.
Summary: A phosphoproteome of yeast spindle pole bodies in G1/S or M phase identifies phosphorylation sites involved in spindle length control and provides direction for future phosphorylation analyses of spindle pole components.
Summary: The effect of atmospheric gusts on the flight trajectories of bumblebees, reporting motion of flight influenced by gusts along with flapping-enabled control strategies that could be necessary elements of flight at this scale.
Summary: The health benefits of dietary polyphenols may be due to their ability to change epigenetic marks in the brain. More studies will clarify how polyphenols from diet can improve mental health.
Summary: A new strategy is decribed, using a new radioprotector (PrC-210) to significantly reduce radiation-induced DNA damage.
Summary: RECK plays critical roles in tumor suppression and embryogenesis, while its mechanisms of actions remain largely obscure. This study has revealed the novel interaction between RECK and ADAMTS10.
Ubiquitin A-52 residue ribosomal protein fusion product 1 (Uba52) is essential for preimplantation embryo development
Summary: Ubiquitin A-52 residue ribosomal protein fusion product 1 (Uba52), a ubiquitin-ribosomal fusion gene, is a major source of ubiquitin protein for covalent modification of proteinaceous substrates recycled by ubiquitin-proteasome system. Using CRISPR/cas9 gene editing tool, we demonstrate that that Uba52 gene is essential in early embryogenesis in mammals.
METHODS & TECHNIQUES
Summary: This article describes the optimization and validation of a protocol for culturing of neurons from transgenic zebrafish for the study of neurodegenerative diseases.
Summary: We present a simple method to estimate an animals’ sensitivity to component colors of RGB images based on visuo-motor reflexes and demonstrate its applicability in Xenopus laevis and Ambystoma mexicanum.