Issues

Summary: Maternal protein deprivation results in low progenitor pooling, and delayed and compromised astrogenesis, suggesting astrocyte impairment as a driver of neurological diseases owing to their imperative roles in normal and pathological situations.

Summary: Shotgun proteomics study of the effect of chronic elevated water temperature identifying 62 differentially expressed ovarian proteins and a model for the proteomic response mediated by PTPN11 and CrkL.

Summary: Fish opercular epithelium ionocytes and accessory cells have WNK family kinases that may regulate paracellular and transcellular ion transport.

Summary: Drosophila Mip120/LIN54, regulates ovarian nurse cell chromosome disassembly and germline-specific gene expression. These functions of Mip120 require its less conserved N-terminus in addition to its CXC DNA-binding and HCH protein-interaction domains.

Summary: The bone morphogenetic proteins (BMPs) are key regulators in cell reprogramming during regeneration of the neural retina and retinal pigment epithelium in the embryonic chick.

Summary: Mechano-sensitive neurons of leech are intrinsically tuned to generate somatic input-output functions with distinct filter properties.

Summary: In able-bodied trunk-flexed gaits, adjustment of trunk kinematic may facilitate negotiation of changes in ground level (10-cm drop and pre/post steps), as reflected in more consistent ground reaction force parameters.

Summary: A toothed jaw-like structure on the male genitalia of the seed beetle Callosobruchus subinnotatus increases female egg production after mating.

Summary: Tau hyper-phosphorylation has been linked to toxicity, but the Tau isoforms, kinases and residues remain unclear. Using the Drosophila model, we find evidence for involvement of TTBK and MARK kinases.

Summary: Five CsPDAT family members were identified from Camelina sativa and they contribute to TAG synthesis in different tissues and various stress responses, offering new targets for lipid metabolic engineering.

Summary: This was one of the first studies that examined transcriptional and physiological responses of Thoroughbred racehorses to six weeks moderate intensity treadmill training in a hypoxia chamber with 15% oxygen.

Summary: Developmental downregulation of LIS1 coordinates the balance between axonal elongation and pruning, which is essential for proper neuronal circuit formation but limits nerve regeneration.

Summary: An easy-to-use ex vivo retinal hypoxia model is introduced that reliably induced retinal damage on a morphological (retinal thickness), and molecular (protein expression and apoptotic markers) level.

Summary: Embryonic cells that transiently express the transcription factor, Tbx6, during the process of gastrulation have been tracked in later development in wild-type and Tbx6 homozygous mutant embryos, where they give rise to the ectopic neural tubes characteristic of the mutant phenotype.

Summary: The density of Wolbachia infection in Drosophila oocytes is significantly increased by dietary sugars, but not sugar alcohols or artificial sweeteners.

Summary: Using the differentiation of huESCs as a model for endoderm formation, we reveal that the transcription factor GATA6 regulates the onset of endoderm gene expression and is required for its viability.

Summary: Effects of starvation on the molecular and biochemical mechanisms of carbohydrate metabolism were regulated by trehalose and glycogen metabolism genes' expression changed in Harmonia axyridis (Pallas).

Summary: Multinucleated osteoclasts form a podosome-derived fusion structure during cell fusion. Juxtaposition of fusion partner cells is probably maintained via force generated by symmetrical retrograde actin flow in the fusion structure.

Summary: Loss of functionality of hagfish slime exudate during storage is driven by mucin vesicle rupture when stabilized in oil and by gradually inhibited skein unraveling when stabilized in buffer.