Issues

Summary: Here we characterise endodermal morphogenesis during somitogenesis stages, and show that PCP signalling plays a mixed role in endoderm development during these stages.

Summary: Hedgehog is a morphogen and oncogene, but what controls its distribution to release sites? We describe a novel, conserved, proteolytic event in Hedgehog processing that controls delivery to target cells.

Summary: ER stress triggers calpain-dependent Bif-1 activation and induction of autophagosome maturation by promoting ATG9/Bif-1 vesicle trafficking and fusion with LC3 bodies.

Summary: Signalling by the nutrient-sensitive mTORC1 pathway mediates the effects of elevated insulin-dependent PI3K on large lipid droplet formation in nutrient-storing nurse cells of the Drosophila ovary.

Summary: We show that the slime secreted by planarian flatworms is supported by a complex meshwork of sulphated polysaccharides. These form an assortment of geodesic structures. Similar structures could be used to provide novel biomimetic drug delivery vehicles.

Summary: The correct allocation and patterning of skeletal elements during development requires a higher dosage of β-catenin than the maturation and mineralization of these primordia.

Summary: Friction and adhesion of a cockroach are analysed in an experimental approach that focuses on the function of the tarsal adhesion-mediating secretion.

Summary: We showed that mouse embryonic dorsal root ganglia contain pluripotent stem cells. We found significant similarities between pluripotent stem cells and neural crest-derived stem cells.

Summary: The span-chordwise bending anisotropy is due to the distribution of resilin patches, the corrugation along the span and the leading edge vein of the venation.

Summary: The study explored the causes of variation in swimming performance with respect to morphological and physiological characteristics, which provides further information about environmental adaptive ability in Gambusia affinis.

Summary: The roles of respective swing leg joints intricately change with increases in running speed during accelerated sprinting.

Summary: The snakehead could survive out of water by breathing air for varying lengths of time, depending on ambient temperature and metabolic demand.

Summary: ‘Disco’ clams are known for their vivid flashing displays. Their vision was examined to see if their display is visible to other disco clams as a signal.

Summary: A map of subunit positional restrictions in Drosophila Augmin shows that Dgt3, Dgt5 and Dgt6 are all required to localise gamma-TuRC to mitotic spindles.

Summary: Trehalose metabolism genes should play a role in osmobiosis regulation and also function within a restricted time frame. Silence of any of these genes will cut down the nematode survival under hypertonic osmotic condition.

Summary: An optical technique for the simultaneous in vivo monitoring of pH in the blood of gill capillaries and interstitial fluid of muscles developed and tested in zebrafish.

Summary: A red fluorescent reporter under the regulatory control of the mouse Hex gene permits identification of different endodermal populations and visualization of dynamic cellular behaviors driving endoderm specification and morphogenesis.

Summary: Induction of pulmonary microthrombosis by three distinct methods enhances HIF-a expression and tumour formation; increases in tumorigenesis that are induced by these thrombotic insults occur in a time- and mode-dependent manner.

Summary: Culturing methods for the propagation of crypt-derived mouse and human enteroids are applicable to large farm and small companion animals, demonstrating conservation of the crypt signaling microenvironment.

Summary: We report variable production efficiencies of CRISPR-Cas9-mediated knock-in mice depending on a series of microinjection timings using vitrified, warmed, and cultured zygotes created via ultra-superovulation and in vitro fertilization.

Summary: A novel method to directly visualize Hedgehog transport in the photoreceptor neurons of living animals offers unprecedented positional and temporal detail of complex phenotypes in real time.