Cover: Light microscopy image at 40× frozen section of e18.5 mouse Col2-Cre−/−;Smad4fl/fl wild-type proximal tibial growth plate. Safranin-O (pink) demonstrates proteoglycans in the extracellular matrix. Fast Green (blue) demonstrates the chondrocyte nuclei. The Safranin-O stain demonstrates normal proteoglycan distribution in the wild-type Col2-Cre−/−;Smad4fl/fl mouse proximal tibial growth plate. On page 358, Whitaker et al. discuss the loss of proteoglycan in the Smad4 conditional knockout mouse. Image provided by Amanda T. Whitaker and licensed under a Creative Commons Attribution 4.0 International licence.
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
Parecoxib inhibits glioblastoma cell proliferation, migration and invasion by upregulating miRNA-29c
Summary: The study indicated that parecoxib may be a potential therapeutic approach to treat GBM by up-regulating miRNA-29c and subsequently inhibiting proliferation, migration and invasion of GBM.
Constitutively active Notch1 converts cranial neural crest-derived frontonasal mesenchyme to perivascular cells in vivo
Summary: Sustained Notch1 activation is sufficient to drive cranial neural crest-derived frontonasal mesenchyme to adopt a perivascular (mural) cell fate in developing chick embryos.
Enhanced store-operated Ca2+ influx and ORAI1 expression in ventricular fibroblasts from human failing heart
Summary: The excessive collagen secretory phenotype found in failing human hearts is associated with ventricular fibroblast remodeling, caused by an elevated influx of intracellular calcium via SOC channels.
The correlation between the length of repetitive domain and mechanical properties of the recombinant flagelliform spidroin
Summary: A study of the relationship between the structure and property of synthetic spider silk-like fibers, which aims to aid with the designing of functional artificial fibers.
Behavioral evidence for a magnetic sense in the oriental armyworm, Mythimna separata
Summary: Responses to changes in the intensity and direction of magnetic fields in the armyworm moth (Mythimna separata) indicate a reliance on a magnetic compass for flight orientation.
Disruption of pdgfra alters endocardial and myocardial fusion during zebrafish cardiac assembly
Summary: The molecular mechanisms regulating cardiac fusion are not well understood. Here, we show that platelet-derived growth factor receptor alpha is essential for normal endocardial and myocardial fusion during zebrafish development.
Smad4 regulates growth plate matrix production and chondrocyte polarity
Summary: Smad4 is a key regulator of extracellular matrix production and chondrocyte proliferation, shape and orientation in the growth plate. Smad4 dysregulation results in skeletal dysplasias, such as Myhre syndrome.
Preference for and learning of amino acids in larval Drosophila
Summary: Drosophila larvae show positive preference but for a few individual amino acids. The preference partially changes depending on larval stage and deprivation. In learning experiments, all 20 tested amino acids were equally rewarding.
Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells
Summary: A mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells, with implications for the maintenance of vascular integrity and vascular disease research.
A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies
Summary: PLK4 and STIL/Ana2 proteins interact to promote centriole duplication. We show that these proteins may homo-multimerise in multiple ways, and that their interaction is likely complex and may differ between species.
METHODS & TECHNIQUES
Quantitative microscopy uncovers ploidy changes during mitosis in live Drosophila embryos and their effect on nuclear size
Summary: A new 3D time-lapse microscopy image analysis pipeline consisting of nuclear segmentation, tracking, annotation and quantification revealed karyotype changes in Drosophila embryos.
Simplified 3D protocol capable of generating early cortical neuroepithelium
Summary: We present a simplified method to generate early neuroepithelium of the cerebellar cortex in a 3D culture using defined medium and minimal addition of growth factors.
The Forest of Biologists
The Forest of Biologists is a biodiversity initiative created by The Company of Biologists, with support from the Woodland Trust. For every Research and Review article published in Biology Open a native tree is planted in a UK forest. In addition to this we are protecting and restoring ancient woodland and are dedicating these trees to our peer reviewers. Visit our virtual forest to learn more.
Propose a new Workshop for 2025
We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
A Year at the Forefront Review
This A Year at the Forefront Review sheds light on the most recent developments in the study of bacterial response to and defence against reactive oxygen and chlorine species. Visit our online Open Access Journal to read all about Sadia Sultana and Jan-Ulrik Dahl's work.
Meeting Review - 14th NYRA Meeting
The 14th NYRA meeting covered a wide range of topics related to male germline research, including the impact of mutations in the male germline on future generations, the use of innovative sequencing tools for the study of male infertility, and the intricate germline epigenome.
Future Leader Reviews
BiO’s Future Leader Reviews help early-career researchers:
- Establish themselves in their field
- Find a foothold in a new area after a subject change post-PhD/postdoc
- Build their profile for grant, fellowship and job applications