Issues

Summary: MiR-93, an oncogene in glioma, is able to confer glioma cells chemoresistance to temozolomide, which may become a promising therapeutic target for glioma.

Summary: Pkaap has a dual role in antimicrobial peptide trafficking and exocytosis, making it an essential component for the secretion of inflammatory mediators and the defence of the host against pathogens.

Summary: We identify genes that are differentially expressed in yeast lacking vacuolar cystine transporter Ers1p in order to find pathways, such as respiration and sulfur regulation, that are associated with cystine homeostasis.

Summary: Activation of PI3K signaling using either a pharmacological inhibitor or genetic ablation of PTEN protects inner ear hair cells from aminoglycoside-induced death.

Summary: We established a method to generate photoreceptor-like cells from peripheral blood mononuclear cells by direct reprogramming to serve in disease modeling of inherited retinal degeneration.

Summary:Leymus chinensis can be harvested at 39 DAPA based on changes in seed colour and a germination test. In actual agricultural production, harvesting is optimal 10 days after the colour of the lemmas reaches yellow and the seed reaches heavy brown.

Summary: Newly-discovered interactions between the Cajal body proteins SMN and coilin with the telomerase complex are reported. These findings suggest that SMN and coilin participate in early steps of telomerase biogenesis.

Summary: We show that the polyamine spermidine, but not spermine, in addition to more general functions during early development, also specifically regulates colour pattern formation in adult zebrafish.

Summary: Previously exposed bighorn sheep can become carriers and transmit respiratory pathogens to naïve animals. Successive crops of lambs acquire pathogens and inadequate passive immunity and subsequently succumb to pneumonia.

Summary: Changes in amino acids, trace elements, nutrient content, serotonin and reproductive genes may substantially affect ovarian and embryonic growth and inhibit development of unfertilized eggs in Reticulitermes chinensis.

Summary: Our study indicates that TiO₂ nanoparticles promote nutrient metabolism in the fat body of silkworms, and provide a reference for studies investigating the biological function of TiO₂ nanoparticles.

Summary: Orally administered royal jelly enlarges non-holometabolous cricket body size, suggesting its conserved effect on body size in insect phyla. This finding contributes to the understanding of regulatory mechanisms on body size.

Summary: Here we characterize Nse5, a component of the Smc5/6 complex. Nse5 interacts with the PIAS E3 SUMO ligases, Siz1 and Siz2, and regulates Smc5 sumoylation.

Summary: Eggs are extremely tolerant to rapid decompression, although larvae may be injured once pressure falls below 40% of the pressure to which they are acclimated.

Summary: Leptin knockdown could become a new approach for the prevention of lung cancer progression, which we have shown is likely to be mediated by inactivation of the Notch and JAK/STAT3 signaling pathways.

Summary: Non-membrane-bound nuclear particles in Xenopus oocytes responsible for RNA transcription, modification and processing contain proteins assembled into amyloids as part of normal development.

Summary: Hirano bodies are F-actin-rich inclusions found in a wide variety of neurodegenerative diseases with a complex physiological role. The composition and formation of Hirano bodies were investigated.

Summary: Fin cryolesion resulted in histolysis and a delayed tissue loss. Despite prolonged destruction of the stump architecture, fin regeneration resumed and was normally completed, revealing robustness of the regenerative capacity.

Summary: This work provides a comprehensive metabolomic study of walnut kernels and reveals most of the carbohydrate and protein-derived carbons were transferred into other compounds during the maturation of walnuts.

Summary: This study used nascent RNA Bru-seq to provide an unprecedented comprehensive view of the dynamic transcriptome as cells reset homeostasis to adjust to new environmental conditions.

Summary: Genome-wide analysis identified 25 ARF gene members (seven transcriptional activators and 18 repressors) in S. miltiorrhiza. The gene structures, functional domains, miRNA targets and expression patterns were analyzed in detail.

Summary: Proteomic analysis of serum samples from fibrotic and cirrhotic rats revealed a reduction in SIPA1L1 concentration with potential use as a marker for early liver fibrosis diagnosis.

Summary: We developed a CRISPR/dCas9-DNMT3A fusion protein to repress the expression of endogenous genes in combination with multiple guide RNAs. This tool can help us elucidate the role of DNA methylation in normal development and disease.

Summary: A 3D platform to characterise biomechanical remodelling of ECM by myofibroblast-like cells, using SHG microscopy, atomic force microscopy and quantitative algorithms to reveal structural, topological and mechanical properties of 3D matrices.