Issues

Summary: This characterization of the early changes in physiological membrane properties of Retzius neurons provides evidence for the oxidative modification of outward potassium channels.

Summary: Specific microstructures of the shark skin surface have certain effects on surface wettability, and play a key role in reducing drag and anti-biofouling properties.

Summary:Drosophila utilises the Ds/Ft system differently as it develops. Localised expression of four-jointed in the tendon cells may help polarise all rows of denticles in late larval stages.

Summary: Sox11 acts to designate neurons in both mouse and frog brains, but orthologs are not functionally redundant. These data show evolutionary conservation of Sox11 function with molecular divergence.

Summary: We describe the establishment of a human TNFα transgenic arthritis mouse model with applications for understanding the role of TNFα in disease progression and developing therapeutic strategies.

Summary: This study shows that the mutational hotspot of ciliary protein RPGR^ORF15, commonly associated with severe blindness, is posttranslationally glutamylated at its C-terminus and is a target of GT335.

Summary: The acid sphingomyelinase trafficking protein sortilin is modulated by chlamydial infection. RNAi-mediated depletion of sortilin does not, however, perturb chlamydial infection.

Summary: Accounting for changes in tidal volume and gas exchange improves the ability to estimate field metabolic rate from respiratory frequency in cetaceans.

Summary: Unlike endothermic species, there is little change in skeletal and cardiac muscle mitochondrial function from the embryonic stage through the first year of life in ectothermic alligators and snapping turtles.

Summary: Dlc1 interacts with several actin filament-associated proteins including Myh9, spectrin and plectin. Transient overexpression of Dlc1 induces an elongated phenotype with elevated Rac1 activation.

Summary: Developmental expression of Pdgfc and Pdgfra is necessary for the development of meninges and the glia limitans basement membrane. Failure of these processes leads to neuronal over-migration.

Summary: Our results suggest that the same animal model of chronic neonatal hyperoxia can be used to simultaneously study lung, brain and retinal injuries related to hyperoxia.

Summary: In this study, we demonstrate that TGF-β1-containing exosomes from high glucose-treated glomerular endothelial cells can activate glomerular mesangial cells to promote renal fibrosis.

Summary: TC-1 silencing inhibited cell proliferation and induced apoptosis in non-small cell lung cancer (NSCLC) both in vitro and in vivo through the Wnt/β-catenin signaling pathway, thereby increasing the susceptibility of NSCLC to radiotherapy.

Summary: Tensin 1 links phosphorylated Cas to actin inward flux, facilitating the force transmission from the motile system (i.e. actomyosin contraction) to the stationary parts (i.e. adhesion complexes) in migrating cells.

Summary: We show that a higher temperature and longer photoperiod are essential for garlic bolting and bulbing. Varied endogenous phytohormone and MeJA levels might lead to the different responses of the studied cultivars to treatments.

Summary: Biosafety of biotechnologically important microalgae was addressed by suicide switch implementation in cyanobacterium Synechocystis sp. PCC 6803. This is the first report of biocontainment safeguards in cyanobacteria.

Summary: We have designed a three dimensional nematode habitat for use in the lab, called NGT-3D, where growth, fertility and lifespan are comparable with the traditional two dimensional lab environment.