Regulatory effects of electronic beam irradiation on mir-21/smad7-mediated collagen I synthesis in keloid-derived fibroblasts
Summary: Using primary keloid-derived fibroblasts, we demonstrate that electronic beam irradiation inhibits the recurrence of keloid scarring by suppressing collagen I expression via mir-21/smad7-mediated p38 activation.
Skeletal muscle growth dynamics and the influence of first-feeding diet in Atlantic cod larvae (Gadus morhua L.)
Summary: Hyperplastic and hypertrophic growth dynamics of red and white muscle were strongly related to cod larval size and corresponded with the metamorphosis process. First-feeding diet quality can prolong effects on muscle growth potential in cod larvae.
Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development
Summary: We generated mice deficient for the secreted protease ADAMTS18 implicated in human disease and show that the gene is required in the development of the lens, lung, and the female reproductive tract.
Summary: Similar to Foxf1 loss, Foxf1 overexpression in mice is lethal. This finding highlights the need to consider alternatives beyond gene therapy to find a cure for alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV).
Alternative exon usage creates novel transcript variants of tumor suppressor SHREW-1 gene with differential tissue expression profile
Summary: Transcripts of the tumor suppressor gene SHREW-1 exist in various splice variants in human and mouse encoding proteins with a differential expression and intracellular localization profile.
Summary: Using spatial and temporally controlled perturbations followed by live cell tracking in vivo, this paper demonstrates that directional movements downstream of Gbx2 and Otx2 are important for otic and lens placode formation.
Establishment of a novel retinoblastoma (Rb) nude mouse model by intravitreal injection of human Rb Y79 cells – comparison of in vivo analysis versus histological follow up
Summary: We present a novel retinoblastoma nude xenograft mouse model which closely resembles the human disease and allows broad application possibilities and a comparison of in vivo and histological analysis.
Summary: MarvelD3 regulates eye morphogenesis through modulation of the JNK pathway, eye-field specification and the balance between cell proliferation and survival.
Oviposition preferences for ethanol depend on spatial arrangement and differ dramatically among closely related Drosophila species
Summary:Drosophila species make dramatically different egg-laying decisions depending on ethanol concentration and the distances between options. Surprisingly, we find that the species with the lowest ethanol tolerance prefers ethanol the most.
Summary: Pulsed ecdysone signaling remodels cell cycle dynamics, causing distinct primary and secondary cell cycle arrests in Drosophila cells, analogous to those observed in the wing during metamorphosis.
Eyes shut homolog is required for maintaining the ciliary pocket and survival of photoreceptors in zebrafish
Summary: The extracellular matrix protein Eyes shut homolog is required for maintaining the integrity of the ciliary pocket and survival of photoreceptors in zebrafish.
A novel mutation in the N-terminal domain of Drosophila BubR1 affects the spindle assembly checkpoint function of BubR1
Summary: We have identified a novel short motif sequence in the Drosophila BubR1 protein which when mutated affects the amount of Cdc20 recruited to the kinetochores and leads to an abrogation of the SAC.
Heterotypic interactions regulate cell shape and density during color pattern formation in zebrafish
Summary: The conspicuous pigmentation pattern of zebrafish is produced by three kinds of interacting pigment cells. Here we address the cellular consequences of these interactions in wild-type fish and mutants with altered pigment patterns.
Summary: Dynamin 2 mutations cause centronuclear myopathy via unclear mechanisms. We show in a mouse model that changes in cytosolic calcium via incorrect membrane permeability correlate with muscle weakness.
Summary: We report the interaction of the microsomal integral membrane protein progesterone receptor membrane component 2 with the nucleoporin ALADIN at the perinuclear ER and nuclear envelope.
The impact of FOXO on dopamine and octopamine metabolism in Drosophila under normal and heat stress conditions
Summary: The transcription factor FOXO affects catecholamine metabolism under normal and heat stress conditions in D. melanogaster, and juvenile hormone (JH) is a mediator of this effect.
Summary: Hygienic behaviour such as the removal of dead and diseased larvae and pupae has an important role in colony health in stingless bees, and it is greater than in unselected honey bee populations
Summary: We show that photoperiod-insensitive components of alleles of Hd1 and Hd2 play an important role in balancing ecological adaptability and high-yield accumulation in rice.
Expression of Cucumber mosaic virus suppressor 2b alters FWA methylation and its siRNA accumulation in Arabidopsis thaliana
Summary: CMV suppressor 2b perturbs host defense by interrupting epigenetic signaling. 2b causes FWA siRNAs sequestration and hypo-methylation of FWA promoter region. It shines light on a hitherto little understood mechanism of viral suppression of host epigenetics.
Summary: A comparison of the kinematics of aquatic and terrestrial feeding in the mudskipper shows how the ancestral kinematic pattern of aquatic feeding is modified to enable the terrestrial capture of prey.
METHODS & TECHNIQUES
Energy metabolic state in hypothermically stored boar spermatozoa using a revised protocol for efficient ATP extraction
Summary: A revised protocol for efficient extraction of ATP from boar spermatozoa is presented that consistently yields high ATP contents and energy charge values from fresh and frozen samples.
A portable infrared photoplethysmograph: heartbeat of Mytilus galloprovincialis analyzed by MRI and application to Bathymodiolus septemdierum
Summary: Infrared photoplethysmogram of Mytilus heart was analyzed by magnetic resonance imaging. Portable photoplethysmographs provide a noninvasive, economical and robust method to monitor the heartbeat of mussels in field experiments.