Issues

Summary: The newly identified Refilin protein family are unique short-lived proteins that complex with Filamin to regulate plasma membrane dynamics though the promotion of Actin filament bundling.

Summary: The anti-cancer drugs doxorubicin and Herceptin can disrupt tight junction formation in cardiac microvascular endothelial cells resulting in increased permeability which could potentially contribute to drug-induced cardiotoxicity.

Summary: This paper demonstrates a functional link between a cancer-associated alteration to the tRNA repertoire and the invasive behaviour of cancer cells by demonstrating that increased tRNA_i^met can drive invasion and metastasis in melanoma cells.

Summary: The inverse expression pattern between matriptase and prostasin during differentiation in human skin demonstrated here provides a stark contrast to their close functional link suggested from mouse models.

Summary: A strain mutated in two decapping activators, previously implicated in P body assembly, has reduced mRNA stability and increased dependence on decapping and Ccr4-dependent deadenylation for mRNA degradation.

Summary: Lipid remodelling according to the gene expression of Tridacna maxima and the fate of its symbiont Symbiodinium may contribute to its resistance during thermal stress.

Summary: Acute severe hypoxia slowed the economical speed (ES) which can minimize energy cost of walking. Muscle O₂ extraction may be one of the determining factors of an individual's ES.

Summary: Using muscle contraction measurements, this work provides evidence that sailfish are most likely unable to reach the extremely high speeds claimed by previous research and popular articles.

Summary: Unlike Rab6-deficiency which affects only apical transport pathways, Syx5-deficiency inhibits all of polarized transport pathways, implying that these two genes are working in distinct stages of intra-Golgi transport.

Summary: Polo-like kinase phosphorylation determines proper centrosome scaffold size and density, but not function or maintenance, in Caenorhabditiselegans embryos.

Summary: The activation of the anaphase-promoting complex drives mitotic exit and here mechanistic aspects of this are explored using CRISPR/Cas9 genetically engineered human null cell lines.

Summary: DNA replication or re-replication of DNA induced after loss of Geminin or CLR4^CDT2 is regulated by the methylation activities of the MLL-WDR5-RBBP5 methyltransferases on histone H3 at lysine 4 (H3K4).

Summary: Cadherin adhesions transduce tension across the junction-actomyosin axis into proportional biochemical responses via α-catenin. Here we show for the first time how this function of the cadherin complex is important during zebrafish morphogenesis.

Summary: Stress granules are formed by mRNAs stalled in translation during stress conditions. P54 RNA helicases from zebrafish reside in cytoplasmic granules and are essential for heat-shock resilience.

Summary: Our work suggests that Polθ upregulation may be crucial for homologous recombination (HR)-proficient cells to better tolerate DNA replication stress, as part of a global gene deregulation response, including HR genes.

Summary: The common Mediterranean mussel, Mytilus galloprovincialis, efficiently generates low Reynolds number inhalant suction flow and unique time-dependent exhalant jet structures.

Summary:Tylototriton verrucosus uses lingual prehension for terrestrial prey capture and switches to suction feeding for aquatic strikes. This flexible prey capture behavior enables efficient food acquisition in two very different habitats.

Summary: This study provided insights into the function of the leptin system in energy metabolism regulation and male pregnancy in lined seahorse (Hippocampus erectus).

Summary: LAMP-2 is required for autophagosome-lysosome fusion. Its absence does not affect the lysosomal SNARE VAMP8 while its interacting partner STX17 is absent from the autophagosomes providing a molecular explanation for this fusion failure.

Summary: The Drosophila homolog of pheromone convertase 2 (PC2), amontillado (Amon), is shown to contribute to Slit processing and further cleavage into an N-Slit, essential for Slit activity in directing muscle patterning.

Summary: Two strains of pea aphid (Acyrthosiphon pisum) show different dispersal strategies, glycogen level and probing behaviors. One strain [Yangling strain (YL)] moves longer and disperses wider than another strain [Lanzhou (LZ)] based on higher glycogen. LZ strain probed more frequently, and identified plant more accurately than YL strain.

Summary: This study suggests that the tree shrew (Tupaia belangeri chinensis) may be useful as a novel animal model for the research of human non-obese non-alcoholic fatty liver disease (NAFLD).