Issues

Summary: Hindsight, the Drosophila homolog of RREB-1, can promote and is required for enterocyte differentiation specifically in the adult midgut. Enterocyte differentiation during the larval/pupal transition does not require Hindsight.

Summary: Using small molecule kinase inhibitors we find that PLK1 and Aurora B cooperate to avoid mitotic slippage upon microtubule depolymerization and to promote their reciprocal recruitment at kinetochores.

Summary: We develop an automated computational image analysis routine to quantify basal body organization, which detects subtle spatial phenotypes resulting from environmental and genetic perturbations.

Summary: Here we show that protein tyrosine phosphatase PTP1B cooperates with β3 integrin to transiently repress RhoA-myosin-dependent contractility, stimulating adhesion and lamellipodium assembly during cell spreading and migration.

Summary: Aerial and terrestrial human running patterns self-select different pleasure running speeds. We suggest the existence of an optimization system allowing association of runners' stride with running speed.

Summary: Epithelial tube size regulation sustains organ physiology. Rac1 limits tube elongation in the fly trachea through restriction of apical membrane growth, and by supporting luminal secretion of chitin modifying enzymes.

Summary: This study was undertaken to detect changes in infectivity induced during long-term cultivation of Chlorella variabilis to alga-free Paramecium bursaria, and its auxotrophy for growth outside the host.

Summary: mRNA expression of atrogin-1 and MuRF1 remains unchanged during hibernation of Daurian ground squirrels, suggesting that stable expression of these genes may facilitate the prevention of SOL atrophy via controlling ubiquitylation of muscle proteins during hibernation.

Summary: We show that hawkmoths fly sideways by rolling in the direction of movement, adding a left- or right-ward component to their net lift vector. The underlying roll maneuvers are produced from a suite of asymmetric wing kinematic changes and are heavily damped.

Summary: Here we describe an easily applicable method that allows C-terminal protein tagging at endogenous loci in a tissue- or cell type-specific manner in Drosophila melanogaster.