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Cover: Ex vivo activation of an unfertilised mature Drosophila melanogaster egg initiates a propagating increase in intracellular calcium. This calcium “wave” starts at the posterior of the egg and moves towards the anterior. Longitudinal-section views at ten second intervals after activation are displayed as Calcium Green-1/Texas Red Dextran ratio images. Increasing Calcium concentration is shown from blue-green-red-white. In this issue, York-Andersen et al. describe how a calcium wave co-ordinates key developmental events in Drosophila egg activation. Photo credit: Richard M. Parton and Clare L. Bromley. See the article by York-Andersen et al. (doi: 10.1242/bio.201411296).
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History of our journals

As our publisher, The Company of Biologists, turns 100 years old, read about Biology Open’s journey and explore the history of each of our sister journals: Development, Journal of Cell Science, Journal of Experimental Biology and Disease Models & Mechanisms.
Offering high-quality peer review through Review Commons

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Daniel Gorelick on Open Access and Read & Publish in Biology Open
Editor-in-Chief, Daniel Gorelick, talks about Biology Open, the importance of Open Access publishing and how The Company of Biologists’ Read & Publish initiative benefits researchers.
Phosphorylation of α-catenin helps cells stick together during mitosis

In this Research Article, Phuong Le, Jeanne Quinn and colleagues found that the adhesion protein α-catenin has a key modification that allows dividing cells to stay better connected to their neighbours, helping the tissue stick together during mechanical stress.
How we support early-career researchers

Biology Open, its sister journals and its not-for-profit publisher, The Company of Biologists, support early-career researchers in numerous ways, helping them grow their network and raise their profile. Find out what we can do to support you.