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Cover image
Cover Image
The node and the notochord are positioned along the midline – the plane of bilateral symmetry in developing vertebrate embryos. The stereotypical shape and placement of these structures are essential for embryonic development. We show that cell–extracellular matrix interactions regulate the shape and orientation of the node along the plane of bilateral symmetry in the mouse, and that this in turn regulates the placement of the notochord as well as its slender, cohesive shape. See the article by Pulina et al. (doi: 10.1242/bio.20148243).
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