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RESEARCH ARTICLES
Inducing bursicon expression using 20-hydroxyecdysone (20E) increased immune response in Macrobrachium rosenbergii against Aeromonas hydrophila
Summary: Ecdysteroid stimulated burs expression and improved the immune response against bacterial challenges.
Ethanol induces subcellular trafficking of the RNA-binding protein, hnRNP A1, in neuronal cells in vitro, but not in the peripubertal rat brain
Summary: Ethanol induces extranuclear hnRNP A1 translocation in neuronal cells, but not in the pubertal rat brain. There are also significant sex differences in hnRNP A1 abundance dependent on brain region.
How octopuses use and recruit additional arms to find and manipulate visually hidden items
Summary: Octopuses use individual arms similarly yet prefer to recruit their nearest-neighboring arm when searching for and interacting with items in a visually occluded environment.
Astrocyte secretome remodeling under iron deficiency: potential implications for brain iron homeostasis
Summary: This study identifies new molecular signals released by brain astrocytes under iron deficiency. These findings offer crucial insights into brain iron control and its relevance to neurological health.
Genetic perturbation of cellular homeostasis regulates integrated stress response signaling to control Drosophila hematopoiesis
Summary: Genetic modulation of cellular homeostasis or cellular aging in a localized or systemic manner impacts stem cell and organ homeostasis.
Gait speed and incline modulate peak deceleration and timing of horizontal center of mass deceleration during double support
Summary: Faster gait speeds and uphill-incline increased step length, shifted maximum deceleration earlier, and enhanced backward forces at toe-off, which may reflect biomechanical adjustments relevant to step-to-step momentum regulation and locomotor efficiency in both healthy gait and rehabilitation contexts.
Metabolic depression and non-specific immune response during hibernation of common Asian toad, Duttaphrynus melanostictus
Summary: Metabolic depression and suppression of non-specific immune response was found in hibernating male common Asian toads with elevated oxidative stress markers in liver tissue indicating tissue-specific immune response.
Macrophages migrate persistently and directionally upon entering 2D confinement in the presence of extracellular matrix
Summary: Macrophages migrate persistently after they transition from 2D adhesion to an adhesive confined environment. Migration is enhanced further if cells sense a fibronectin gradient. This may have relevance to immune and cancer cell behavior.
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Fast & Fair peer review
Biology Open's Editor-in-Chief Daniel Gorelick explains why the journal's Fast & Fair peer review experiment is such an exciting initiative.
Biology Open 2024 – a year in review

In this Editorial, Editor-in-Chief Daniel Gorelick reviews Biology Open’s performance for the year 2024.
Nicotine enhances the lethal effect of a parasitic fungus in ants

Jason Rissanen and Dalial Freitak show that nicotine pollution in the environment could have a big impact on the health of ants, as it makes diseases more deadly for them.
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Our not-for-profit publisher, The Company of Biologists, has designed the event carbon calculator to support the creation of sustainable events. The tool is still in its beta stage. Please test it and let us know if you have any feedback.