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Cover image
Cover Image
Diamond-backed terrapins (Malaclemys terrapin) live exclusively in tidally influenced habitats along the United States East and Gulf coasts. Organic osmolytes play an important role in maintenance of body fluid homeostasis during exposure to high salinity in dynamic estuarine environments. An understanding of the diamond-backed terrapin's osmoregulatory strategy enhances our ability to assess how this species of conservation concern may respond to projected changes in coastal habitats due to sea level rise. From a paper by Pierre et al. (2025). Photograph by L.A. Harden. Image licensed under a Creative Commons Attribution 4.0 International license. - PDF Icon PDF LinkTable of contents
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EDITORIALS
MEETING REVIEW
2024 Argentine Group for Extracellular Vesicles (GAVE) Workshop: promoting science in challenging times
Summary: This Meeting Review article showcases the latest workshop of the Argentine Group for Extracellular Vesicles, emphasizing its impact in fostering national and international collaborations.
RESEARCH ARTICLES
Osmoregulation in the estuarine diamond-backed terrapin across a broad range of naturally occurring salinities
Summary: We investigated the osmoregulatory strategy of diamond-backed terrapins and consider our findings in the context of energetics and resilience to climate change in this estuarine species.
Establishment of an intragastric surgical model using C57BL/6 mice to study the vaccine efficacy of OMV-based immunogens against Helicobacter pylori
Summary: This paper introduces an animal model using surgical intervention by directly injecting the inoculum to the stomach. This resulted in severe infection in 7 days. The model is efficient for prophylactic and therapeutic studies.
Intracellular trafficking of furin enhances cellular intoxication by recombinant immunotoxins based on Pseudomonas exotoxin A
Summary: The protease furin can act as an intracellular chaperone during the intoxication pathway of recombinant immunotoxins based on Pseudomonas exotoxin A. Using a HEK293 furin knockout cell line, we conclude that both furin cleavage and trafficking contribute to intoxication.
Hip stabilization in an australopithecine-like hip: the influence of shape on muscle activation
Summary: The shape of an australopithecine pelvis in a modern human body produces higher hip muscle activations for gluteus medius, but lower activations for gluteus maximus.
A feed-forward loop between Toll/NF-κB and Rac1 promotes epithelial to mesenchymal transition of Ras-oncogenic hindgut enterocytes in Drosophila
Summary: A feed-forward loop between Toll/NF-κB and Rac1 signalling drives Ras-induced cell invasion by coordinating cytoskeletal changes, adhesion loss, and basement membrane degradation in Drosophila hindgut enterocytes.
Generation and characterization of a DYNLT1-knockout mouse model reveals electrophysiological alterations and potential mechanistic contributors to atrial fibrillation
Summary: This study first generated a DYNLT1-KO spontaneous atrial fibrillation (AF) mouse model via CRISPR/Cas9, highlighting the DYNLT1-TMCO1 axis in ER calcium overload and offering new insights into AF mechanisms.
Filtration and respiration of filter-feeding marine invertebrates are linked through allometric power-law functions
Summary: Based on published data, we verify the hypothesis of equal allometric power-law exponents. The available b-values for very different taxonomic groups of filter feeders (bivalves, ascidians, crustaceans, polychaetes, jellyfish) support the hypothesis of b1≈b2.
A novel 14-3-3θ phosphomimetic mouse model demonstrates social dominance defects
Summary: Increased 14-3-3θ phosphorylation is seen in several neurodegenerative diseases. A novel 14-3-3θ phosphomimetic mouse, which was developed for this study, showed social dominance deficits.
Maternal protein restriction affects the differentiation of cells in the epididymal epithelium lining of 44-day-old rats
Summary: Even after post-weaning nutritional recovery, maternal protein restriction impairs epididymal epithelial cell differentiation in 44-day-old rats - an age at which full differentiation is normally expected.
Ammonia transport mediated by urea transporter A isoforms
Summary: The central message of this work is that UT-A2 and UT-A3 function as ammonia channels and employ a transport mechanism similar to UT-B.
Ethanol downregulates gastrula gene expression and cell movement, causing symptoms of foetal alcohol spectrum disorders
Summary: Ethanol alters gene expression and cell movement at the gastrula stage in zebrafish embryos.
Persistent enteric neuroinflammation chronically impairs colonic motility in a pyridostigmine bromide-induced mouse model of Gulf War illness
Summary: This study reveals how a one-time toxic exposure causes lasting gut nerve damage and inflammation, offering insight into chronic gastrointestinal symptoms seen in Gulf War veterans.
Muscle forces and the demands of turning while walking
Summary: Force patterns of the muscles that stabilize the hip and ankle show differences in timing and magnitude compared to force patterns of straight-path walking.
METHODS & TECHNIQUES
EyeHex toolbox for complete segmentation of ommatidia in fruit fly eyes
Summary: Tran and colleagues present EyeHex, a software toolbox for supervised and adaptive segmentation of ommatidia in fruit fly compound eyes.
FIRST PERSON
Fast & Fair peer review
Biology Open 2024 – a year in review
In this Editorial, Editor-in-Chief Daniel Gorelick reviews Biology Open’s performance for the year 2024.
Nicotine enhances the lethal effect of a parasitic fungus in ants
Jason Rissanen and Dalial Freitak show that nicotine pollution in the environment could have a big impact on the health of ants, as it makes diseases more deadly for them.
Event carbon calculator
Our not-for-profit publisher, The Company of Biologists, has designed the event carbon calculator to support the creation of sustainable events. The tool is still in its beta stage. Please test it and let us know if you have any feedback.
