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Cover image
Cover Image
Confocal microscopy image depicting LC3 staining (red) in Neuro-2a cell lines under heat shock conditions. The nucleus is counterstained with DAPI (blue). From a paper by Pratibha Bhadauriya and colleagues (2025). Image licensed under a Creative Commons Attribution 4.0 International license. - PDF Icon PDF LinkIssue info
EDITORIAL
The story of Biology Open: a conversation with past and present Editors-in-Chief
REVIEW
Sox8: a multifaceted transcription factor in development and disease
Summary: Sox8 is a transcription factor involved in processes of organogenesis and differentiation during development. Recent studies suggest its involvement in diseases like Multiple Sclerosis, cancer and infertility, underscoring its potential as a therapeutic target.
RESEARCH ARTICLES
Enteropathogenic E. coli effector Map interacts with Rab13 and regulates the depletion of the tight junction proteins occludin and claudins via cathepsin B-mediated mechanisms
Summary: Enteropathogenic E. coli infection causes acute diarrheal disease in infants. This paper shows that the EPEC effector Map interacts with the recycling endosome marker Rab13 and disrupts the intestinal barrier by cathepsin B-mediated depletion of tight junction proteins.
Traumatic injury leads to ovarian cell death and reproductive disturbances in Drosophila melanogaster
Summary: Traumatic injury leads to increased ovarian cell death and disruptions in egg laying and ovulation in Drosophila.
Ccn2a acts downstream of cx43 to influence joint formation during zebrafish fin regeneration
Summary: This paper identifies Ccn2a, a multifunctional protein implicated in osteoarthritis, as a mediator of skeletal patterning during zebrafish fin regeneration.
The combinatorial binding syntax of transcription factors in forebrain-specific enhancers
Summary: The co-occurrence patterns of tissue-relevant transcription factor binding motifs can serve as a general framework for tissue-specific enhancer discovery.
Glycogen synthase is required for heat shock-mediated autophagy induction in neuronal cells
Summary: This study shows that heat shock increases glycogen synthase (GS) activity and levels. This study also shows that HSF1 regulates GS activation, and that GS is necessary for autophagy induction and cell survival during heat shock stress.
From early development to maturity: a phenotypic analysis of the Townes sickle cell disease mice
Summary: This longitudinal characterisation provides insights into the pathophysiology of sickle cell disease in the Townes mouse model, which is useful for guiding design and interpretation of preclinical studies and is of potential relevance in understanding disease progression.
Impairment of proteasome-associated deubiquitinating enzyme Uchl5/UBH-4 affects autophagy
Summary: Modulation of UPS via pharmacological or genetic impairment of the proteasome-associated DUB Uchl5/UBH-4 affects autophagy in human cells and in a tissue-differential manner in C. elegans.
LRRC56 deletion causes primary ciliary dyskinesia in mice characterized by dynein arms defects
Summary: The authors generated LRRC56-knockout mice using the CRISPR/Cas9 nuclease system and found it led to a range of conditions consistent with primary ciliary dyskinesia.
Gene expression differences in the olfactory bulb associated with differential social interactions and olfactory deficits in Pax6 heterozygous mice
Summary: Pax6 heterozygous mutant mice display aberrant social interactions and olfactory deficits caused by an imbalance between neuronal excitation and inhibition, synaptic dysfunction, and alterations in epigenetic regulation.
A high-resolution bovine mitochondrial co-expression network
Summary: Characterising the architecture of the mitochondrion using highly conserved patterns of mRNA co-expression.
Increased expression of the small lysosomal gene SVIP in the Drosophila gut suppresses pathophysiological features associated with a high-fat diet
Summary: Increasing lysosome activity in the fly midgut offsets negative effects of an obesogenic high-fat diet.
Proximity proteomics provides a new resource for exploring the function of Afadin and the complexity of cell-cell adherens junctions
Summary: Afadin BioID reveals new candidate adherens junction proteins, opening leads for new research and suggesting overlap with other cell junctions.
METHODS & TECHNIQUES
FIRST PERSON
CORRECTION
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Biology Open’s journey and explore the history of each of our sister journals: Development, Journal of Cell Science, Journal of Experimental Biology and Disease Models & Mechanisms.
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Daniel Gorelick on Open Access and Read & Publish in Biology Open
Phosphorylation of α-catenin helps cells stick together during mitosis
In this Research Article, Phuong Le, Jeanne Quinn and colleagues found that the adhesion protein α-catenin has a key modification that allows dividing cells to stay better connected to their neighbours, helping the tissue stick together during mechanical stress.
How we support early-career researchers
Biology Open, its sister journals and its not-for-profit publisher, The Company of Biologists, support early-career researchers in numerous ways, helping them grow their network and raise their profile. Find out what we can do to support you.
