EDITORIAL
RESEARCH ARTICLES
Chromosome number alterations cause apoptosis and cellular hypertrophy in induced pluripotent stem cell models of embryonic epiblast cells
Summary: Reversine-treated human induced pluripotent stem cells as models of aneuploid epiblast suggest apoptosis and cellular hypertrophy caused by imbalanced gene dosages due to chromosome number variations as possible mechanisms of abortive embryonic development.
Cellular signalling protrusions enable dynamic distant contacts in spinal cord neurogenesis
Summary: This study reveals dynamic cellular protrusions in mouse spinal cord neural progenitors that extend Notch signalling beyond adjacent cells, possibly contributing to periodic HES5 expression patterns during neurogenesis.
Air–liquid interface culture combined with differentiation factors reproducing intestinal cell structure formation in vitro
Summary: Physiological functions of intestinal cells can be reproduced, but their complex crypt-villus-like structure is difficult to mimic. A combination of air–liquid interface culture and differentiation-promoting factors makes it possible.
Microbiome transplants may not improve health and longevity in Drosophila melanogaster
Summary: Microbiome transplants have been proposed as a method to mitigate age-related health declines. Here we determine that microbiome transplants generally fail to extend lifespan and improve health in Drosophila melanogaster.
α-catenin phosphorylation is elevated during mitosis to resist apical rounding and epithelial barrier leak
Summary: Adherens junction regulation during cell division relies on force-dependent unfolding of the mechanosensitive scaffold protein α-catenin. Here, we show that α-catenin modification by phosphorylation also increases during mitosis to reinforce epithelial barrier function.
Gene expression and DNA methylation changes in response to hypoxia in toxicant-adapted Atlantic killifish (Fundulus heteroclitus)
Summary: This study reveals how evolved resistance to toxicants in killifish may compromise their ability to respond to hypoxia, highlighting trade-offs that impact survival in stressed coastal environments.
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Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register to join us in March 2025 in Liverpool, UK. Register by 28 February 2025.
Daniel Gorelick on Open Access and Read & Publish in Biology Open
A new model for cephalopod neurobiology
Fabián Vergara-Ovalle and colleagues show the distribution of the nitric oxide system within the nervous system, particularly in areas associated with olfactory and visual information processing, in Octopus maya. Since these octopi can be cultured in the lab, they represent a valuable model for studying cephalopod neurobiology.
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