Issues

Summary: Identification of TAK1 downstream targets essential for muscle growth and hypertrophy has broad implications for understanding muscle diseases including the identification of potentially druggable targets for those diseases.

Summary: Our work demonstrates a role for Foxg1a in developing and regenerating mechanosensory hair cells.

Summary: The bony septae underlying the frontal and interparietal bones of the bison skull help to dissipate the impact energy produced when two bison engage in head-to-head fighting. Oblique impacts, whereby one bison uses its interparietal bone to hit another bison in the side of the head, produce the highest peak strains.

Summary: This research provides valuable insights into Octopus maya digestive enzyme functions, representing a significant advancement in formulating diets crucial for successful octopus farming that may help fully understand its physiology.

Summary: Honeybee reproduction is key to ensuring the productivity on hives and the maintenance of pollination capacity. Understanding how queen ovaries develop from embryo to adult provides information about ovary stucture, and the nature and formation of the germline.

Summary: Hair cells in two different cilia gene mutants show decreased survival potentially due to mitochondria disruption. In contrast to this, hair cell development in these mutants appears normal.

Summary: Contemporary cardiac injury models in zebrafish often lack the important element of myocardial hypoxia. We introduce a larval zebrafish model in which cardiac damage is induced in by exposure to severe ambient hypoxia.

Summary: Duchenne muscular dystrophy is a devastating disorder that currently has limited treatment options. RNA sequencing and downstream analysis in iSkM and mdx samples revealed HMGB1 may be a relevant treatment biomarker.

Summary: Single-copy transgene integration is achieved at user-specified genomic loci to facilitate multiple downstream applications.

Summary: This study provides an atlas of lateral root development of the model grass species Brachypodium distachyon.

Summary: We developed a novel model of acute myeloid leukaemia in adult zebrafish where RUNX1:RUNX1T1 and NRAS(G12D) cooperate to increase penetrance and self-renewal to create a leukaemia that can be transplanted.

Summary: Coordination during the swing phase was more modifiable than during stance, with earlier reversal of antiphase thigh-thigh and backwards thigh-shank and shank-foot rotations in late swing observed with improved performance.

Summary: The BMP signaling pathway is highly dynamic in the early Drosophila embryo. Live cell imaging quantifies these dynamics and points to a memory mechanism to regulate gene expression.

Summary: Viability of coral hybrids in the ocean indicates that they could be a useful tool for reef conservation.

Summary: The cephalopod eye lens is unique because it has evolved as a compound structure with two physiologically distinct segments. To help elucidate structure-function relationships in the cephalopod lens we conducted multiple structural investigations on squid.

Summary: Discover a new automated workflow for high throughput tracking and quantification of single cells and phagosomes in infectious disease research.

Summary: Modern methods of nonlinear regression allow investigators to perform comprehensive studies of allometric variation without transforming the original data.

Summary: The study shows that male rats can be safely catheterised via the urethra with the aid of a microscope and microsurgical instruments for both visual and tactile feedback.