Issues
A YEAR AT THE FOREFRONT
RESEARCH ARTICLES
foxg1a is required for hair cell development and regeneration in the zebrafish lateral line
Summary: Our work demonstrates a role for Foxg1a in developing and regenerating mechanosensory hair cells.
Theoretical model of impact mitigation mechanisms inherent to the North American bison skull
Summary: The bony septae underlying the frontal and interparietal bones of the bison skull help to dissipate the impact energy produced when two bison engage in head-to-head fighting. Oblique impacts, whereby one bison uses its interparietal bone to hit another bison in the side of the head, produce the highest peak strains.
Evaluation of Octopus maya enzyme activity of the digestive gland and gastric juice
Summary: This research provides valuable insights into Octopus maya digestive enzyme functions, representing a significant advancement in formulating diets crucial for successful octopus farming that may help fully understand its physiology.
Development of germline progenitors in larval queen honeybee ovaries
Summary: Honeybee reproduction is key to ensuring the productivity on hives and the maintenance of pollination capacity. Understanding how queen ovaries develop from embryo to adult provides information about ovary stucture, and the nature and formation of the gremlin.
The role of cilia in the development, survival, and regeneration of hair cells
Summary: Hair cells in two different cilia gene mutants show decreased survival potentially due to mitochondria disruption. In contrast to this, hair cell development in these mutants appears normal.
A larval zebrafish model of cardiac physiological recovery following cardiac arrest and myocardial hypoxic damage
Summary: Contemporary cardiac injury models in zebrafish often lack the important element of myocardial hypoxia. We introduce a larval zebrafish model in which cardiac damage is induced in by exposure to severe ambient hypoxia.
High mobility group box 1 (HMGB1) is a potential disease biomarker in cell and mouse models of Duchenne muscular dystrophy
Summary: Duchenne muscular dystrophy is a devastating that currently has limited treatment options. RNA sequencing and downstream analysis in iSkM and mdx samples revealed HMGB1 may be a relevant treatment biomarker.
Instantaneous visual genotyping and facile site-specific transgenesis via CRISPR-Cas9 and phiC31 integrase
Summary: Single-copy transgene integration is achieved at user-specified genomic loci to facilitate multiple downstream applications.
An atlas of Brachypodium distachyon lateral root development
Summary: This study provides an atlas of lateral root development of the model grass species Brachypodium distachyon.
Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic NRAS in zebrafish myeloid leukaemia
Summary: We developed a novel model of acute myeloid leukaemia in adult zebrafish where RUNX1:RUNX1T1 and NRAS(G12D) cooperate to increase penetrance and self-renewal to create a leukaemia that can be transplanted.
Lower-limb coordination changes following a 6-week training intervention that elicited enhancements to maximum velocity sprint performance
Summary: Coordination during the swing phase was more modifiable than during stance, with earlier reversal of antiphase thigh-thigh and backwards thigh-shank and shank-foot rotations in late swing observed with improved performance.
Dynamics of BMP signaling and stable gene expression in the early Drosophila embryo
Summary: The BMP signaling pathway is highly dynamic in the early Drosophila embryo. Live cell imaging quantifies these dynamics and points to a memory mechanism to regulate gene expression.
Interspecific hybridisation provides a low-risk option for increasing genetic diversity of reef-building corals
Summary: Viability of coral hybrids in the ocean indicates that they could be a useful tool for reef conservation.
Membrane structures and functional correlates in the bi-segmented eye lens of the cephalopod
Summary: The cephalopod eye lens is unique because it has evolved as a compound structure with two physiologically distinct segments. To help elucidate structure-function relationships in the cephalopod lens we conducted multiple structural investigations on squid.
FIRST PERSON
METHODS & TECHNIQUES
da_Tracker: Automated workflow for high throughput single cell and single phagosome tracking in infected cells
Summary: Discover a new automated workflow for high throughput tracking and quantification of single cells and phagosomes in infectious disease research.
Data transformation and model selection in bivariate allometry
Summary: Modern methods of nonlinear regression allow investigators to perform comprehensive studies of allometric variation without transforming the original data.
A novel technique for atraumatic transurethral catheterisation of male rats
Summary: The study shows that male rats can be safely catheterised via the urethra with the aid of a microscope and microsurgical instruments for both visual and tactile feedback.
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The power of planaria
In their Research Article, Orel Benita and colleagues obtain the first recording of well-defined extracellular multiunit activity from the freshwater planarian brain by a straight-forward technique. These traits combined with their exceptional regeneration capabilities, allow for neurobiological experiments not possible in any other model organism such as an electrophysiological recording from planaria with two heads that control a shared body.
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