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Cover image
Cover Image
An eye antennal imaginal disc from Drosophila is shown, anterior to the left. Three nuclear proteins have been labelled by indirect immunofluorescence. Blue labels the Drosophila E protein Daughterless (Da), a ubiquitous basic Helix-Loop-Helix (bHLH) transcription factor that acts as the heterodimer partner for many other bHLH transcription factors that control specific cell fates. Red shows Extramacrochaetae (Emc), a widely expressed Helix-Loop-Helix protein that forms inactive heterodimers with bHLH proteins and so provides a barrier to many cell fate specifications. Emc levels are lower in a stripe across the eye portion of the eye antennal disc that marks the onset of retinal differentiation. Within this stripe, known as the morphogenetic furrow, a zinc finger protein Senseless, shown in green, turns on and is maintained by more mature cells to the right, as the morphogenetic furrow moves to the left. Senseless marks one of the retinal photoreceptor cell types as it continues to differentiate after the morphogenetic furrow has passed. The paper by Reddy, Bhattacharya and Baker shows that many effects of emc mutations reflect unrestrained activity of Da. Creative Commons Attribution 4.0 International license.
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The power of planaria
In their Research Article, Orel Benita and colleagues obtain the first recording of well-defined extracellular multiunit activity from the freshwater planarian brain by a straight-forward technique. These traits combined with their exceptional regeneration capabilities, allow for neurobiological experiments not possible in any other model organism such as an electrophysiological recording from planaria with two heads that control a shared body.
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