Empowering tomorrow's leaders: the impact of the 15th Network of Young Researchers in Andrology (NYRA) meeting on male reproductive health and interdisciplinary collaboration
Summary: This paper provides an overview of the 15th NYRA meeting. The paper provides a general background and justification for the existence of our network.
Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations
Summary: Whole-mount preparations and serial histologic sections in pudgy (pu/pu) mice demonstrate localized paravertebral longitudinal cartilage/bone accumulations (PVLC/BAs) invariably associated with branched, fused and asymmetrically spaced ribs emanating laterally from them.
Summary: Immunity is vital when migrating to new environments. It is costly and competitive to other physiological processes. Here, we bring new evidence on this process in migratory birds.
ASCL2 is a key regulator of the proliferation–differentiation equilibrium in the esophageal epithelium
Summary: ASCL2 is a key regulator of esophageal epithelial homeostasis. ASCL2 overexpression impairs differentiation, reduces cell proliferation and enhances resistance to radiation and chemotherapeutic drugs.
Summary: Steroid exposure during embryonic development influences a variety of processes and here we show that the developing extraembryonic membranes respond to corticosterone early in development.
The Nucleosome Remodelling and Deacetylation complex coordinates the transcriptional response to lineage commitment in pluripotent cells
Summary: We show that the chromatin remodeller NuRD suppresses transcriptional noise, primes genes for activation and coordinates the transcriptional response in individual cells during the exit from naive pluripotency.
Summary: Aging disrupts spatial regulation of Notch activation in the C. elegans germline, leading to the mislocation of the Notch-responsive GSC pool, leading to reproductive decline, which is mainly due to an age-associated DTC/niche nuclear shift and its structural changes.
The influence of carbon dioxide on cerebral metabolism and oxygen consumption: combining multimodal monitoring with dynamic systems modelling
Summary: Systems modelling of near-infrared spectroscopy changes in hemoglobin oxygenation and cytochrome oxidase redox state are consistent with carbon dioxide decreasing cerebral oxygen consumption by inhibiting mitochondrial respiration at succinate dehydrogenase.
Summary: In a series of life span survival assays on different diets, this study shows that other divalent metals in the diet, especially calcium and magnesium, protect adult Drosophila from manganese toxicity.
Summary: The Drosophila GEF Schizo removes N-cadherin during myoblast fusion. We found that Schizo interacts with Abi to antagonize Schizo function and to inhibit the removal of N-cadherin during embryogenesis.
METHODS & TECHNIQUES
BBQ methods: streamlined workflows for bacterial burden quantification in infected cells by confocal microscopy
Summary: Improving bacterial burden quantification (BBQ): introducing automated, unbiased methods for precise assessment within host cells, enhancing our understanding of host–pathogen interactions.
Summary: This paper describes the development of a new genetically encoded necrosis sensor in Drosophila.