Issues
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Cover image
Cover Image
A selection of covers from Professor Steven Kelly’s time as Editor-in-Chief of Biology Open. Image licensed by a Creative Commons Attribution 4.0 International license.
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EDITORIALS
REVIEWS
No-cost meals might not exist for insects feeding on toxic plants
Summary: Detection of physiological and ecological costs of chemical defence in insects under an ecophysiological framework for the better understanding of the ecology and evolution of plant-insect-antagonist interaction.
Maintenance of neuronal fate and transcriptional identity
Summary: This Review explores recent progress in understanding the mechanisms that maintain neuronal cell fate and gene expression, discussing the activating and repressive factors involved, relevance to disease, and outstanding questions.
RESEARCH ARTICLES
Loss of flrt2 gene leads to microphthalmia in zebrafish
Summary: flrt2 is necessary for the normal development of the zebrafish eyes since it is strongly expressed in the retina and deletion of flrt2 causes microphthalmia in zebrafish
An ethogram identifies behavioural markers of attention to humans in European herring gulls (Larus argentatus)
Summary: Urbanised herring gulls successfully benefit from anthropogenic food sources. We show that human food-centred behaviours directly modulate the attentional states of such gulls.
Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish
Summary: Identification of various new gene sets regulated by the transcription factors Dlx3b/4b during early inner development in zebrafish.
Tbx5 overexpression in embryoid bodies increases TAK1 expression but does not enhance the differentiation of sinoatrial node cardiomyocytes
Summary: The sinoatrial node transcriptional program is activated by blocking phosphorylation of TAK1 during cardiac differentiation of pluripotent cells, providing a simplified protocol for the in vitro differentiation of cardiac pacemakers.
The insulin receptor regulates the persistence of mechanical nociceptive sensitization in flies and mice
Summary: This paper demonstrates a conserved role for the insulin receptor in regulating the persistence of injury-induced mechanical nociception in flies and mice.
METHODS & TECHNIQUES
Ac/Ds transposition for CRISPR/dCas9-SID4x epigenome modulation in zebrafish
Summary: The Ac/Ds transposition system, which enables the continuous expression of guide RNAs for CRISPR/Cas perturbation, is adapted to examine the epigenome in zebrafish.
A monoclonal antibody raised against human EZH2 cross-reacts with the RNA-binding protein SAFB
Summary: We report that a broadly used rabbit monoclonal antibody raised against human EZH2 cross-reacts with Scaffold Attachment Factor B in mouse embryonic stem cells under buffer conditions that are commonly used for chromatin immunoprecipitation.
FIRST PERSON
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The power of planaria
In their Research Article, Orel Benita and colleagues obtain the first recording of well-defined extracellular multiunit activity from the freshwater planarian brain by a straight-forward technique. These traits combined with their exceptional regeneration capabilities, allow for neurobiological experiments not possible in any other model organism such as an electrophysiological recording from planaria with two heads that control a shared body.
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