- PDF Icon PDF LinkIssue info
Open questions in marine mammal sensory research
Summary: The report summarizes future areas of marine mammal sensory research including aerial sensing in fully aquatic species, size-related questions in large species, seemingly vestigial structures, and concerted action of senses.
Peripodial adherens junctions regulate Ajuba-Yorkie signaling to preserve fly eye morphology
Summary: Adherens junctions in the peripodial epithelium of the Drosophila eye disc promote normal morphology of the retinal epithelium and fly eye via a Jub-Wts-Yki-ECM signaling axis.
New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape
Summary: We present new genome-edited mouse models in which the amino acid residue lysine 50 is replaced with arginine 50 (K50R) in either eIF5A1 or eIF5A2 proteins. This mutation prevents the spermidine-dependent post-translational formation of hypusine, a unique lysine derivative that is necessary for activation of eIF5A1 and eIF5A2.
Generation of induced pluripotent stem cell-derived beta-cells in blood amino acids-like medium
Summary: We used a blood amino acids-like medium and found that it is useful to efficiently differentiate human iPSCs into the definitive endoderm, and to generate functional pancreatic beta-cells.
Over-expressing NadA quinolinate synthase in Escherichia coli enhances the bioelectrochemistry in microbial fuel cells
Summary: This article is a report on exploring the application of gene modification in microbial fuel cells (MFCs), which expands the study of gene modification in improving MFC performance.
Cerebral organoids in primary progressive multiple sclerosis reveal stem cell and oligodendrocyte differentiation defect
Summary: Using cerebral organoids derived from patients with multiple sclerosis we detected that p21 decrease may induce a disruption of the stem cell cycle leading to a defect of oligodendrocyte differentiation.
Defective COX1 expression in aging mice liver
Summary: Mitochondrial function is severely affected in aging livers. Hence, the current study uses a Nanopore sequencing based approach for mitochondrial transcriptomics. The analyses show that a decrease of the Cox1 transcript correlates with reduced respiratory complex IV activity in older mice livers.
Movement-synchronized cerebellum rhythm coordinates multi-joint movements in young and elderly adults
Summary: We investigated the effect of synchronized cerebellum activity on the coordination of multi-joint leg movements in young and elderly people. The synchronized activity was shown to reduce fluctuations in movement synchrony.
Parental exposure to ocean acidification impacts gamete production and physiology but not offspring performance in Nematostella vectensis
Summary: Ocean acidification (OA) threatens the reproduction of marine invertebrates. We investigated how simulated OA affected the reproduction of a model sea anemone, revealing effects with mixed implications for fitness.
The Forest of Biologists
We are excited to announce the launch of The Forest of Biologists, a new biodiversity initiative created with support from the Woodland Trust, aiming to counteract nature loss and safeguard some of the most critically endangered ecosystems for future generations. View our virtual forest here. For every Research Article and Review/Commentary article that is published in Biology Open, a native tree is planted in a forest in the UK.
Propose a new Workshop for 2025
Do you have an idea for a Workshop? We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
Resources for early-career researchers
BiO and our publisher The Company of Biologists offer a number of practical ways to help you meet the unique needs and challenges you may encounter as an early-career researcher (ECR). Visit our dedicated ECR webpage to find out more.
Have a paper that has been reviewed elsewhere? BiO is pleased to consider such manuscripts for fast-tracked decision making. Send us your manuscript together with the full set of reviews and decision letters, and we will make an initial decision in one week (or less).
Future Leader Reviews
BiO’s Future Leader Reviews help early-career researchers:
- Establish themselves in their field
- Find a foothold in a new area after a subject change post-PhD/postdoc
- Build their profile for grant, fellowship and job applications