Summary: BioStruct-Africa has been building capacity in structural biology for Africa-based biologists and researchers.
Beyond bold versus shy: Zebrafish exploratory behavior falls into several behavioral clusters and is influenced by strain and sex
Summary: Prior work described individual differences in zebrafish exploratory behavior as bold or shy. Here, we find four categories better describe their behavior: bold, shy, active explorers, and wall-huggers.
Tissue-specific transcriptome profiles identify functional differences key to understanding whole plant response to life in variable salinity
Summary: Differences in seagrass leaf, meristem and root transcriptomes across variable salinities are due to tissue-specific processes. Leaf meristem contained the broadest process range, indicating preferential use for inferring plant-wide activity.
Summary: This study provides an effective and feasible method for development of human nasal organoids from chronic rhinosinusitis patients, suitable for phenotypic high-throughput screening and drug-response research.
Summary:Musclebow2 clonal cell lineage analysis is introduced to reveal the cellular dynamics of skeletal muscle formation, repair and maintenance throughout the life of zebrafish.
Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFRα signalling in cerebellar development
Summary: Mice lacking PDGF-C develop cerebellar hypoplasia and malformation. In addition, the ventricular zone close to the rhombic lip suffer from ependymal denudation.
A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation
Summary: A hypomorphic mutation in Pold1 caused reduced size and abnormal morphology of gastrulating mouse embryos, highlighting the importance of coordinated embryo growth, lineage specification, and tissue morphogenesis for normal embryogenesis.
SPS1 deficiency-triggered PGRP-LC and Toll expression controls innate immunity in Drosophila S2 cells
Summary: This study provides insights into the function of SEPHS1 regulating the innate immune system of Drosophila through controlling PGRP-LC and Toll transcription even without infection.
The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization
Summary: The Parkinson's disease LRRK2 signaling pathway converges upon the formation of a complex at the subdistal appendage of the mother centriole which causes centrosomal deficits and impairs appropriate cell polarization.
METHODS & TECHNIQUES
Chromatin dynamics through mouse preimplantation development revealed by single molecule localisation microscopy
SUMMARY: We have applied super-resolution microscopy to analyse changes in the state of chromatin during the first stages of mouse development, from the two-cell stage to the blastocyst.