A YEAR AT THE FOREFRONT
Summary: An a Year at the Forefront Review highlighting promising advances in engineering photosynthesis made in the period February 2021 to January 2022.
Summary: Are you an early-career researcher considering preprinting, but unsure how to approach conversations about the possibility? Here, we discuss preprinting and provide tips to enable you to take ownership over the process.
Influence of weighted downhill running training on serial sarcomere number and work loop performance in the rat soleus
Summary: An investigation of adaptations in mechanical function induced by a novel method of weighted downhill running training in rats, and the connections to adaptations in muscle architecture.
Comparative transcriptomics of tropical woody plants supports fast and furious strategy along the leaf economics spectrum in lianas
Summary: The full-length fraction of liana transcriptomes mapped on a protein–protein interactome revealed the nature of their convergence through distinct sets of expressed and downregulated genes not observed in free-standing plants.
Summary: Coilin acts as an upstream regulator of the NF-kB pathway through positive regulation of miR-517-3p leading to increased NF-kB signaling and higher expression of sFlt-1.
Summary: A minimal SH3-HOOK fragment of Dlg is sufficient to support epithelial polarity through mechanisms independent of the PP1 phosphatase.
Summary: We showed that the formation of cytoneme-like protrusions, which function in cell signaling, is induced by LAR and clarified that it is LAR dimerization which promotes protrusion formation.
Alterations in lifespan and sleep:wake duration under selective monochromes of visible light in Drosophila melanogaster
Summary: Monochromes influence light:dark phase-dependent changes in active-sleep time, alongside lowering lifespan in fruit flies and dark phase anticipation under blue and green lights, highlighting the detrimental effects of artificial lights.
EPCAM and TROP2 share a role in claudin stabilization and development of intestinal and extraintestinal epithelia in mice
Summary: Closely related paralogs EPCAM and TROP2 have distinct but overlapping functions in claudin stabilization and mouse postnatal development.
Genetic analysis of Caenorhabditis elegans Haspin-like genes shows that hasp-1 plays multiple roles in the germline
Summary: New mutations in the C. elegans homologs of the histone kinase Haspin show roles in spermatogenesis and germline proliferation and genetic interactions with mutations in related genes.
Summary: Loss of vitamin D receptor, alone or in combination with either an inflammatory agent or the ApcPirc/+ rat intestinal tumor model, did not enhance tumor occurrence, growth, or progression.
Introducing blood flow in kidney explants by engraftment onto the chick chorioallantoic membrane is not sufficient to induce arterial smooth muscle cell development
Summary: The chorioallantoic membrane assay has been previously used to verify the vascularization potential of engineered organoids. We identified severe limitations of this assay, such as a lack of arterial maturity.
Summary: We report the nuclear localization of the histamine receptor 2 (H2R) in lymphatic endothelial cells and other cell types and ligand-dependent effects on H2R nuclear localization kinetics, with histamine-H2R binding serving as a critical step.
METHODS & TECHNIQUES
Summary: Here, we present the improvements of surgery and post-operative care to minimize intraoperative mortality and to maximize survival rates of the one-kidney one-clip (1K1C) mouse model of human chronic hypertension.