Heterogeneous substrate adhesivity. Representative z-slice of confocal imaging of f-actin (red) and DNA (blue) of a keratocyte cell sheet. Picture captures leader cells with no followers at that plane. Followers are at higher z-planes and hence not visible in this image. X-Z sections (see paper) reveal bridge-like pluricellular structures. The paper by Chakraborty et. al. explores how such cell arrangements influence the speed and tension distribution of leader cells. Image licensed under a Creative Commons Attribution 4.0 International license.
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Heart rate as a proxy for estimating oxygen consumption rates in loggerhead turtles (Caretta caretta)
Summary: The relationship between oxygen consumption rate and heart rate in the loggerhead turtle.
Initial parasitic behaviour of the temporary social parasitic ant Polyrhachis lamellidens can be induced by host-like cuticles in laboratory environment
Summary: This study found that initial parasitic behaviour, namely ‘rubbing behaviour’, of the temporary social parasitic species Polyrhachis lamellidens can be induced by exposure to a combination of chitin and host cuticular compounds.
Revisiting the flight dynamics of take-off of a butterfly: experiments and CFD simulations for a cabbage white butterfly
Summary: We conducted measurements of the taking-off motion of a butterfly (Pieris rapae) and numerical simulations using a more sophisticated computational model than existing butterfly models.
Presynaptic HCN channels constrain GABAergic synaptic transmission in pyramidal cells of the medial prefrontal cortex
Summary: This study we uncover a novel function of HCN channels in layer 5–6 medial prefrontal cortex (mPFC) circuit: regulate inhibitory input of pyramidal neurons.
Ocean acidification affects the expression of neuroplasticity and neuromodulation markers in seabream
Summary: Ocean acidification alters fish behaviour. We show altered expression of genes involved in neuroplasticity and neuromodulation in fish exposed to high PCO2, highlighting their possible roles in such behavioural alterations.
Mutations in Drosophila tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia
Summary: Defects in the polynucleotide kinase, CLP1, and the tRNA splicing endonuclease (TSEN) complex display overlapping phenotypes in both vertebrates and invertebrates.
Perinatal exposure to synergistic multiple stressors leads to cellular and behavioral deficits mimicking Schizophrenia-like pathology
Summary: This study reports that exposure to perinatal multi-hit stress (protein malnourishment and immune stress) causes changes in the hippocampal cells alongside behavioral deficits which are also observed in Schizophrenic condition.
Effect of heterogeneous substrate adhesivity of follower cells on speed and tension profile of leader cells in primary keratocyte collective cell migration
Summary: Understanding how leading cells in keratocyte cell sheets are affected when their followers ‘ride’ on them and how this alters their basal membrane's height fluctuations and fluctuation tension.
shRNAs targeting mouse Adam10 diminish cell response to proinflammatory stimuli independently of Adam10 silencing
Summary: Use of several specific shRNAs is not enough to escape a pitfall of their off-target activity: the case of Adam10 and Adam17 silencing.
DNMT1 is a negative regulator of osteogenesis
Summary: DNMT1 is overexpressed in sponge bone of people and mice with senile osteoporosis and required for suppression of osteoblast (OB) differentiation of mesenchymal stem cells (MSCs) and osteoprogenitors.
METHODS & TECHNIQUES
Inertial biometry from commercial 3D body meshes
Summary: Using commercial digital 3D body meshes, body segment inertial parameters of humans and animals can be estimated, expanding the possibilities and the spectrum of species considered in biomechanics research.
A deep-dive into fictive locomotion – a strategy to probe cellular activity during speed transitions in fictively swimming zebrafish larvae
Summary: This approach combines fictive locomotion, elicited through the optomotor response, and calcium imaging or optogenetics, to investigate the role of neuronal populations in shaping motor output.
Genetically inducible and reversible zebrafish model of systemic inflammation
Summary: A new transgenic zebrafish model enables the regulated induction and resolution of systemic inflammation.
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