Issues

Summary: We describe recent advances and new directions in extracellular matrix research presented at the 2021 hybrid scientific meeting organized by the American Society for Matrix Biology.

Summary: This Review proposes the hypothesis that developmental disorders caused by haploinsufficiency of transcriptional regulators result from disrupted bistability (i.e. disrupted positive feedback or cooperativity) in the gene-regulatory network of the underlying cell fate decision.

Summary: Serotonin is a neurotransmitter associated usually with our mood, yet recent evidence indicates that serotonin regulates the cell uptake process, endocytosis, diversifying the potential roles of serotonin throughout the body.

Summary: HMBPP potentiated Vγ9Vδ2 T cell cytotoxicity towards colon cancer cells, assessed at the single cell level using a novel flow cytometric method. Dimethylallyl monophosphate is a phosphoantigen and freshly thawed serum supplementation improves proliferation.

Summary: Soluble (s) RAGE reduced tubular injury in mice acute kidney injury (AKI) model. sRAGE attenuated hypoxia induced damage and accelerated proliferation in tubular epithelial cells. sRAGE may be a potential therapeutic option for AKI.

Summary: SW1353 chondrocyte-like cells respond to shear and compressive stimulation through changes in diverse metabolic pathways between 15 and 30 minutes of stimulation.

Summary: Here we investigate expression of two apolipoprotein genes by microglia in the zebrafish model during normal development, and in contexts of pharmacological manipulations that target candidate regulatory receptors.

Summary: The Drosophila genes rumpel, bumpel and kumpel, that encode SLC5A proteins expressed in overlapping sets of CNS glial cells act in partially redundant manner during locomotor control and oogenesis.

Summary: A human iPSC resource to study the cellular basis of neurodevelopmental defects in Lowe syndrome.

Summary: Early developmental abnormalities in myotonic dystrophy type 1 are reiterated in vitro in myotubes differentiated from human embryonic stem cells that carry the mutation.