Issues

Summary: We describe that KDM5A and KDM5B histone-demethylases contribute to hydroxyurea-induced replication stress tolerance, in part by regulating expression of ribonuclease reductase subunit RRM2.

Summary: The caenacin antimicrobial peptide CNC-4 is regulated by a mitochondrial recovery pathway and exhibits broad antibacterial activity.

Summary: The actin-membrane linker protein ezrin-related signaling plays a critical role in podocyte apoptosis through regulation of Nox4 expression and ROS production.

Summary: An integrative picture about the mechanisms operating in the hippocampal vasculature under normal and pathological scenarios is achieved by the computational dissection of microarray data corresponding to whole tissue samples and focusing on gene splice forms.

Summary: A subpopulation of pluripotent cells of the embryo give rise to the primordial germ cells (PGCs), the precursors of the sperm and egg, which pass on heritable genetic information to the next generation. To determine how PGCs are first segregated from the soma, we investigated BMP, MAPK and WNT signaling over time in PGCs and their surrounding niche in vitro and in vivo at single-cell resolution.

Summary: We report that auxin and auxin-inducible protein degradation tools alter lifespan in C. elegans.

Summary: This is a study on candidate genotyping of sheep with different tail types in China.