KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance
Summary: We describe that KDM5A and KDM5B histone-demethylases contribute to hydroxyurea-induced replication stress tolerance, in part by regulating expression of ribonuclease reductase subunit RRM2.
A nematode-derived, mitochondrial stress signaling-regulated peptide exhibits broad antibacterial activity
Summary: The caenacin antimicrobial peptide CNC-4 is regulated by a mitochondrial recovery pathway and exhibits broad antibacterial activity.
Summary: The actin-membrane linker protein ezrin-related signaling plays a critical role in podocyte apoptosis through regulation of Nox4 expression and ROS production.
Mapping the transcriptomic changes of endothelial compartment in human hippocampus across aging and mild cognitive impairment
Summary: An integrative picture about the mechanisms operating in the hippocampal vasculature under normal and pathological scenarios is achieved by the computational dissection of microarray data corresponding to whole tissue samples and focusing on gene splice forms.
Summary: A subpopulation of pluripotent cells of the embryo give rise to the primordial germ cells (PGCs), the precursors of the sperm and egg, which pass on heritable genetic information to the next generation. To determine how PGCs are first segregated from the soma, we investigated BMP, MAPK and WNT signaling over time in PGCs and their surrounding niche in vitro and in vivo at single-cell resolution.
Summary: We report that auxin and auxin-inducible protein degradation tools alter lifespan in C. elegans.
Genome wide association study for the identification of genes associated with tail fat deposition in Chinese sheep breeds
Summary: This is a study on candidate genotyping of sheep with different tail types in China.