Issues

Summary: A discussion of the role and regulation of myosin super relaxation in biology, evolution, human disease, and cardiac therapeutics.

Summary: We investigated the stability of amino acids in serum samples that underwent prolonged storage at 4°C and 22°C, and repeated freeze-thaw cycles at −80°C using stable isotope iTRAQ labeling and liquid chromatography tandem mass spectrometry.

Summary: Nodal signaling is involved in the delimitation of the blastula cell populations that give rise to the brain and axial mesoderm in Xenopus.

Summary: Tspan18 is a transmembrane protein with highly restricted expression in endothelial cells and a critical regulator of VEGF and Notch pathways. It regulates artery–vein specification, vessel patterning and vessel stability.

Summary: The unique histological structures in derimis, subcutis and coccygeal artery of the tail skin are related to the caudal autotomy mechanism in the cotton rat.

Summary: The level of sex differences in metabolic traits is affected by flight in Cynopterus sphinx, a finding that has general implications for sex-specific life-history evolution in fruit bats.

Summary: Nicotine, a substance present in tobacco, resembles insecticide compounds such as neonicotinoids, and affects the heart function in Drosophila melanogaster.

Summary: The single-cell expression atlas in the cardiomyocytes generated from human iPSCs provide potential carcinogenic information for the clinical application of human iPSC-derived cells.

Summary: This paper provides quantitative data on the growth of 58 structures of the human embryonic heart between weeks 4 and 8 of development.

Summary: This study developed a novel approach to estimate selection strength over time and applied it on the evolution of human pigmentation.

Summary: Here we report on a method to culture human PAX3-FOXO1 fusion-positive rhabdomyosarcoma cells in three dimensions, and use these rhabdospheres as a novel tool to study their stemness and chemoresistance signaling mechanisms.

Summary: Auxin, commonly used to induce conditional protein degradation, promotes ER stress resistance in C. elegans through the unfolded protein response (UPR).

Summary: Using Drosophila as a model system, we identify F-actin and microtubules as important determinants of how cells and tissues respond to Shroom induced contractility.

Summary: We describe a method to co-culture glioblastoma stem cells with human cerebral organoids in order to model tumor complexity and recapitulate cellular heterogeneity in vitro.

Summary: The authors describe a fluorescently tagged Ku70 protein to monitor replication stress in live S. pombe cells.

Summary: Description and testing of a 3D printed uniaxial stretcher designed for the microscopic and biochemical analysis of mammalian cells subjected to mechanical stretch.