Issues
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Cover image
Cover Image
Marcetteau et al., show that Arf6 is required for wing patterning in response to Wingless signalling during Drosophila wing development. The image represents the pattern of Senseless (red) and Wingless (blue) expression in both Wild-Type (to the left), and Arf6 mutant (to the right) cells. Graphic by Julien Marcetteau. Image licensed under a Creative Commons Attribution 4.0 International license.
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RESEARCH ARTICLES
Multiple neural bHLHs ensure the precision of a neuronal specification event in Caenorhabditis elegans
Summary: During neuronal specification, the combined action of several neural bHLHs ensures the robust activation of terminal selector transcription factor expression and prevents the activation of deleterious genes.
Dynamic shapes of the zygote and two-cell mouse and human
Summary: Mouse zygote morphokinetics were measured during interphase, the mitotic period, cytokinesis, and two-cell stage. Sequences of rounder–distorted–rounder shapes were revealed, as were changing patterns of cross section area. Some of these movements were sporadically also seen in human zygotes with abnormal numbers of pronuclei and the two-cell stages that developed from these compromised human zygotes.
Alterations in brain glycogen levels influence life-history traits and reduce the lifespan in female Drosophila melanogaster
Summary: This study demonstrates that Drosophila melanogaster females with altered levels of brain glycogen display a shortened lifespan, increased resistance to starvation, and higher levels of oxidative stress than male flies. Thus, metabolic processes like the glycogen synthesis pathway could influence sex-specific traits in animals.
Palmitoylated small GTPase ARL15 is translocated within Golgi network during adipogenesis
Summary: ARL15 (GTPase ARF family) is associated with adipose traits. ARL15 is palmitoylated, localised to Golgi in preadipocytes and translocated to other Golgi compartments during differentiation. ARL15 interacts with ER-localised ARL6IP5.
Modest sexual size dimorphism and allometric growth: a study based on growth and gonad development in the wolf spider Pardosa pseudoannulata (Araneae: Lycosidae)
Summary: Our findings indicated that growth and developmental differences between sexes appeared at early life stages, and there was allometric growth in the carapace, abdomen, and gonads between males and females.
Cellular senescence limits translational readthrough
Summary: We report that senescence and the RB pathway reduce translational readthrough (TR) limiting proteome diversity and the expression of TR proteins such as Ago1X required for cancer cell proliferation.
Arf6 is necessary for senseless expression in response to wingless signalling during Drosophila wing development
Summary: Arf6 is necessary for the patterning of the wing margin by Wingless in Drosophila melanogaster, acting downstream of stabilized Armadillo but upstream or at the level of Pangolin activity.
METHODS & TECHNIQUES
A new method to localise and quantify oxidative stress in live juvenile mussels
Summary: A new method to quantify reactive oxygen species in live mussels using image analysis. The unusual fixation step allows for in situ staining, followed by image analysis in the laboratory.
FIRST PERSON
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