Issues

Summary: This review evaluated the molecular mechanisms that may explain the vulnerability and susceptibility of the entorhinal cortex to early neurodegeneration during the pathogenesis of Alzheimer's disease.

Summary: Nucleoside reverse transcriptase inhibitors (NRTIs) that are important components of anti-retroviral therapies also cause peripheral sensory neuropathies (PSN). This article investigates ways in which NRTIs may cause PSN and outlines ways to better understand the mechanisms underlying it.

Summary: We here demonstrate that the interaction of INPP5E with ARL13B is crucial for its retention on the ciliary membrane but dispensable for its entry into cilia.

Summary: Conserved focal adhesion genes, mys and Fak, enable efficient wound repair by inducing polyploid cell growth via cell fusion and Yki-dependent endoreplication.

Summary:Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1) overexpression skews APP processing towards the non-amyloidogenic pathway. Increasing ABCC1 expression or activity may prevent or attenuate Alzheimer's disease symptoms.

Summary: A stem cell based in vitro model of NAFLD recapitulates regulatory networks and suggests a steatosis associated phenotype. AdipoRon treatment influences metabolism, immune system, cell stress and signalling.

Summary: Retinitis pigmentosa (RP) is a human disease resulting in blindness, which affects 1 in 4.000 people worldwide. So far >90 genes have been identified that are causally related to RP. Mutations in the splicing factor PRPF31 are linked to RP11. We induced mutations in the Drosophila orthologue Prp31 and show that flies heterozygous for Prp31 undergo light-dependent retinal degeneration. Degeneration is associated with increased accumulation of the light-sensitive molecule, rhodopsin 1. In fact, reducing rhodopsin levels by dietary intervention modifies the extent of retinal degeneration. This model will further contribute to better understand the aetiology of the human disease.

Summary: Using a simple biomechanical model, we predict the compressive stress on vertebrates’ intervertebral discs loaded by all cranial masses being held anywhere between fully upright and horizontal bow.

Summary:Chelonoidis carbonaria aortic rings release endothelium-derived catecholamines that modulate vascular smooth muscle reactivity.

Summary: Physiologically-relevant doses of the plasticizing agent BPA inhibit stress granule formation in response to a secondary acute stress, indicating BPA may affect the way human cells cope with cellular stress.

Summary: Our results clearly showed parental alarm calls varied as the breeding cycle progressed in the common kestrel, and further suggested offspring numbers influenced parental nest defense.

Summary: Spermatogonial stem cell transplantation in mice with germline ablation by genetic modification of a specific gene.

Summary: Knockout of Ctdp1 reveals its essential role in mammalian embryogenesis and regulation of the cell cycle.