Issues
-
Cover image
Cover Image
Lysosomal exocytosis in hypertrophic chondrocytes, mediated at least partially by VAMP8, causes release of lysosomal hydrolases that can contribute to cartilage resorption in the growth plate. This image shows double immunofluorescence labelling of lysosome-associated membrane protein 1 (LAMP1) (red) colocalised with the v-SNARE protein VAMP8 (green) at the cell surface of cultured mouse epiphyseal chondrocytes. Merged data are shown in the right-hand column. VAMP8 partially colocalises with LAMP1 in perinuclear regions of the cell under basal conditions (row 1). Ionomycin treatment induces the redistribution of VAMP8 and LAMP1 to the plasma membrane, where they are colocalised (row 2). This redistribution is blocked by the addition of EGTA (row 3), and by preincubation of the cells with the microtubule-depolymerising agent nocodazole prior to ionomycin treatment (row 4). See the article by Bastow et al. (doi: 10.1242/bio.2012547).
- PDF Icon PDF LinkTable of contents
RESEARCH ARTICLE
Advertisement
A new Editor-in-Chief and new future for Biology Open

Find out more about the changes at the helm of Biology Open from departing Editor-in-Chief Steve Kelly and Director of The Company of Biologists Laura Machesky. And read our interview with new Editor-in-Chief Daniel Gorelick.
A Year at the Forefront of Plasmodesmal Biology

Andrea Paterlini presents a short overview of recent discoveries, innovations, community resources and hypotheses in the field of plasmodesmata biology.
Future Leader Review: Glial plasticity at nervous system transition zones

In our most recent Future Leader Review, Laura Fontenas from Florida Atlantic University highlights recent work on glial cell migration in and out of the spinal cord.
Future Leader Reviews
Our Future Leader Reviews help early-career researchers:
- Establish themselves in their field
- Find a foothold in a new area after a subject change post-PhD/postdoc
- Build their profile for grant, fellowship and job applications
Sustainable Conferencing Initiative

Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share experience about how new technologies and conference formats work in practice.