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Cover image
Cover Image
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Close ModalHuman mutations affecting the RPGRIP1 interactome cause severe ocular-renal diseases. Disease mutations in RPGRORF15 (red) and its partner, RPGRIP1α1 (green), promote their subcellular uncoupling and delocalizationthroughout the cytosolic compartment (background image). Foreground image shows an axial view along thecentral shaft of the propeller structure of the RCC1-homogous domain (RHD) of RPGR isoforms (red ribbon)superimposed on the template and known structure of RCC1 (yellow ribbon). See the article by Patil et al. (doi: 10.1242/bio.2011489).
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