ABSTRACT
First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping researchers promote themselves alongside their papers. Martha S.C. Xelhuantzi is first author on ‘ High-resolution live cell imaging to define ultrastructural and dynamic features of the halotolerant yeast Debaryomyces hansenii’, published in BiO. Martha conducted the research described in this article as an exchange undergraduate student in Chris MacDonald's lab at the University of York. She is now an undergraduate student at the Instituto Tecnológico y de Estudios Superiores de Monterrey, Campus Ciudad de México, Mexico City, investigating cellular processes and advanced imaging techniques to enhance biotechnological applications and translational research.
Martha S. C. Xelhuantzi
Describe your scientific journey and your current research focus
I am an undergraduate student from Mexico, pursuing a BA in Biosciences at the Tecnológico de Monterrey (ITESM). My program emphazises the generation of novel healthcare solutions through research and entrepreneurship projects. Through my studies, I have focused on microbial culture, mammalian cell culture and imaging techniques. I have participated in various research programs, both in Mexico and abroad, including at the MD Anderson Cancer Center in Houston and the University of York. During my 5-month stay at the University of York, I was involved in several projects, including the one we are currently presenting. For the future, I aim to work on fundamental science projects, especially those focused on cellular processes that could lead to real-world applications, and that involve advanced imaging techniques.
My ultimate goal is to bridge the gap between fundamental research and clinical practice.
Who or what inspired you to become a scientist?
My parents and grandmother, all biologists, were my primary inspiration, particularly my mother. From a young age, she allowed me to observe her research, teaching, and conference activities. It was through my mother that I first used a microscope; even before I learned how to divide and multiply, I was looking at pollen samples under a microscope. This early exposure sparked my curiosity, fueled my thirst for knowledge, and deepened my passion for science. Over the years, I have realized through personal experience that many biological and disease processes remain poorly understood. By exploring these areas, I hope to contribute to improving the quality of life and health outcomes for many people. My ultimate goal is to bridge the gap between fundamental research and clinical practice. This aspiration continues to drive my passion for scientific discovery.
How would you explain the main finding of your paper?
Debaryomyces hansenii is a species of yeast used in the food and biotechnology industries that has been difficult to study. Our team combined special dyes and advanced imaging techniques to see the intracellular organization of these cells and measure some of the biological processes. We were able to identify and visualize important cell structures, such as mitochondria, nuclei, vacuoles and the cell wall. These techniques also allowed us to understand key processes like cell division and how certain elements of the cell are inherited. We also optimized a microscopy technique that measures cellular features in a ‘label-free’ manner, which is particularly useful when studying organisms that are difficult to manipulate and assess with typical methods. In combination, these approaches revealed a better understanding of this particular yeast, which will be useful to its various industrial applications. Beyond this, our approach transcends yeast and could be applied to many other biological systems, especially as most understanding of cell biology is restricted to a tiny fraction of experimental models.
What are the potential implications of this finding for your field of research?
The knowledge we gained about D. hansenii opens the door to optimizing processes in the biotechnology and food industries. Additionally, the methods we used here can be applied to study other organisms that are not easily genetically manipulated, broadening the scope of research in cellular biology. This can lead to new insights and advancements in understanding complex cellular processes in various organisms.
The knowledge we gained about D. hansenii opens the door to optimizing processes in the biotechnology and food industries.
Which part of this research project was the most rewarding?
The most rewarding part of this research was the opportunity to conduct experiments independently as an undergraduate student. This project was my first experience being deeply involved in all aspects of a project, from performing experiments to writing the paper and presenting the findings. It provided me with hands-on experience and a sense of accomplishment. Additionally, I discovered a particular interest in microscopy, which has helped me begin to define the path I want to take in research. Furthermore, this experience allowed me to explore how science is conducted in other countries, broadening my perspective and enriching my approach to scientific inquiry. Finally, before my time in the MacDonald lab, I had never presented my research externally. Although I was nervous attending my first national conference, presenting a poster and discussing my work with numerous cell biologists was incredibly rewarding.
What do you enjoy most about being an early-career researcher?
As an early-career researcher, I enjoy the flexibility that comes with having a ‘clean slate’, which allows me the freedom to explore different opportunities, areas of knowledge and techniques. This career stage offers invaluable experiences, allowing me to work in various labs around the world and learn from experienced researchers. The chance to gain insights and guidance from seasoned scientists is incredibly enriching. This process helps me build a strong foundation for my future research career, shaped by the advice and experiences of those who have come before me.
What piece of advice would you give to the next generation of researchers?
My main advice to the next generation of researchers is to find a mentor who can guide and support you. A good mentor can provide invaluable insights, help you navigate challenges, and encourage your growth as a scientist. I've been lucky enough to have had a couple of exceptional mentors who have positively transformed my career path. Additionally, seize every opportunity that comes your way. In the worst-case scenario, you gain valuable experience; in the best-case scenario, your career path and life could be completely transformed. Remember that a research career is both mentally and emotionally demanding, so it's important to nurture your relationships outside of work and maintain your hobbies. Striking a balance between your professional and personal life is crucial for long-term success and well-being. Personally, I loved being in the lab and on the microscopes at the technology facility in York, but it was equally important for me to have fun with new friends, participate in the Taylor Swift Society events, and take small trips around the UK.
What's next for you?
My immediate plan is to finish my undergraduate program in Mexico in the coming months. After that, I aim to apply to postgraduate programs to further my education and research skills. I am extremely excited about the possibilities that the future holds.
Martha S. C. Xelhuantzi's contact details: Instituto Tecnológico y de Estudios Superiores de Monterrey, Campus Ciudad de México, Mexico City, Mexico, 14380. E-mail: [email protected]
